Human Apolipoprotein E (APOE) activation kit by CRISPRa

CAT#: GA100247

APOE CRISPRa kit - CRISPR gene activation of human apolipoprotein E

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: APOE
• Locus ID: 348
• Kit Components:

  GA100247G1, Apolipoprotein E gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100247G2, Apolipoprotein E gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100247G3, Apolipoprotein E gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000041, NM_001302688, NM_001302689, NM_001302690, NM_001302691
• UniProt ID: P02649
• Synonyms: AD2; APO-E; LDLCQ5; LPG
• Summary: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]