Human Serum Amyloid P (APCS) activation kit by CRISPRa

CAT#: GA100226

APCS CRISPRa kit - CRISPR gene activation of human amyloid P component, serum

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: APCS
• Locus ID: 325
• Kit Components:

  GA100226G1, Serum Amyloid P gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100226G2, Serum Amyloid P gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100226G3, Serum Amyloid P gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001639
• UniProt ID: P02743
• Synonyms: HEL-S-92n; PTX2; SAP
• Summary: The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]