Human ADCY5 activation kit by CRISPRa

CAT#: GA100073

ADCY5 CRISPRa kit - CRISPR gene activation of human adenylate cyclase 5

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ADCY5
• Locus ID: 111
• Kit Components:

  GA100073G1, ADCY5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100073G2, ADCY5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100073G3, ADCY5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199642, NM_183357
• UniProt ID: O95622
• Synonyms: AC5; FDFM
• Summary: This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]