PAR2 (F2RL1) (NM_005242) Human Untagged Clone

CAT#: SC322345

F2RL1 (untagged)-Human coagulation factor II (thrombin) receptor-like 1 (F2RL1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PAR2
• Synonyms: GPR11; PAR2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322345 TGAAACCTAACCCGCCCTGGGGAGGCGCGCAGCAGAGGCTCCGATTCGGGGCAGGTGAGA
  GGCTGACTTTCTCTCGGTGCGTCCAGTGGAGCTCTGAGTTTCGAATCGGCGGCGGCGGAT
  TCCCCGCGCGCCCGGCGTCGGGGCTTCCAGGAGGATGCGGAGCCCCAGCGCGGCGTGGCT
  GCTGGGGGCCGCCATCCTGCTAGCAGCCTCTCTCTCCTGCAGTGGCACCATCCAAGGAAC
  CAATAGATCCTCTAAAGGAAGAAGCCTTATTGGTAAGGTTGATGGCACATCCCACGTCAC
  TGGAAAAGGAGTTACAGTTGAAACAGTCTTTTCTGTGGATGAGTTTTCTGCATCTGTCCT
  CACTGGAAAACTGACCACTGTCTTCCTTCCAATTGTCTACACAATTGTGTTTGTGGTGGG
  TTTGCCAAGTAACGGCATGGCCCTGTGGGTCTTTCTTTTCCGAACTAAGAAGAAGCACCC
  TGCTGTGATTTACATGGCCAATCTGGCCTTGGCTGACCTCCTCTCTGTCATCTGGTTCCC
  CTTGAAGATTGCCTATCACATACATGGCAACAACTGGATTTATGGGGAAGCTCTTTGTAA
  TGTGCTTATTGGCTTTTTCTATGGCAACATGTACTGTTCCATTCTCTTCATGACCTGCCT
  CAGTGTGCAGAGGTATTGGGTCATCGTGAACCCCATGGGGCACTCCAGGAAGAAGGCAAA
  CATTGCCATTGGCATCTCCCTGGCAATATGGCTGCTGATTCTGCTGGTCACCATCCCTTT
  GTATGTCGTGAAGCAGACCATCTTCATTCCTGCCCTGAACATCACGACCTGTCATGATGT
  TTTGCCTGAGCAGCTCTTGGTGGGAGACATGTTCAATTACTTCCTCTCTCTGGCCATTGG
  GGTCTTTCTGTTCCCAGCCTTCCTCACAGCCTCTGCCTATGTGCTGATGATCAGAATGCT
  GCGATCTTCTGCCATGGATGAAAACTCAGAGAAGAAAAGGAAGAGGGCCATCAAACTCAT
  TGTCTCTGTCCTGGCCATGTACCTGATCTGCTTCACTCCTAGTAACCTTCTGCTTGTGGT
  GCATTATTTTCTGATTAAGAGCCAGGGCCAGAGCCATGTCTATGCCCTGTACATTGTAGC
  CCTCTGCCTCTCTACCCTTAACAGCTGCATCGACCCCTTTGTCTATTACTTTGTTTCACA
  TGATTTCAGGGATCATGCAAAGAACGCTCTCCTTTGCCGAAGTGTCCGCACTGTAAAGCA
  GATGCAAGTATCCCTCACCTCAAAGAAACACTCCAGGAAATCCAGCTCTTACTCTTCAAG
  TTCAACCACTGTTAAGACCTCCTATTGAGTTTTCCAGGTCCTCAGATGGGAATTGCACAG
  TAGGATGTGGAACCTGTTTAATGTTATGAGGACGTGTCTGTTATTTCCTAATCAAAAAGG
  TCTCACCACATACCATGTGGATGCAGCACCTCTCAGGATTGCTAGGAGCTCCCCTGTTTG
  CATGAGAAAAGTAGTCCCCCAAATTAACATCAGTGTCTGTTTCAGAATCTCTCTACTCAG
  ATGACCCCAGAAACTGAACCAACAGAAGCAGACTTTTCAGAAGATGGTGAAGACAGAAAC
  CCAGTAACTTGCAAAAAGTAGACTTGGTGTGAAGACTCACTTCTCAGCTGAAATTATATA
  TATACACATATATATATTTTACATCTGGGATCATGATAGACTTGTTAGGGCTTCAAGGCC
  CTCAGAGATGATCAGTCCAACTGAACGACCTTACAAATGAGGAAACCAAGATAAATGAGC
  TGCCAGAATCAGGTTTCCAATCAACAGCAGTGAGTTGGGATTGGACAGTAGAATTTCAAT
  GTCCAGTGAGTGAGGTTCTTGTACCACTTCATCAAAATCATGGATCTTGGCTGGGTGCGG
  TGCCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCAGGCAATCACTTGAGGTCA
  GGAGTTCGAGACCAGCCTGGCCATCATGGCGAAACCTCATCTCTACTAAAAATACAAAAG
  TTAACCAGGTGTGTGGTGCACGTTTGTAATCCCAGTTACTCAGGAGGCTGAGGCACAAGA
  ATTGAGTATCACTTTAACTCAGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCACCACTGC
  ACTCCAGCTTGGGTGATAAAATAAAATAAAATAGTCGTGAATCTTGTTCAAAATGCAGAT
  TCCTCAGATTCAATAATGAGAGCTCAGACTGGGAACAGGGCCCAGGAATCTGTGTGGTAC
  AAACCTGCATGGTGTTTATGCACACAGAGATTTGAGAACCATTGTTCTGAATGCTGCTTC
  CATTTGACAAAGTGCCGTGATAATTTTTGAAAAGAGAAGCAAACAATGGTGTCTCTTTTA
  TGTTCAGCTTATAATGAAATCTGTTTGTTGACTTATTAGGACTTTGAATTATTTCTTTAT
  TAACCCTCTGAGTTTTTGTATGTATTATTATTAAAGAAAAATGCAATCAGGATTTTAAAC
  ATGTAAATACAAATTTTGTATAACTTTTGATGACTTCAGTGAAATTTTCAGGTAGTCTGA
  GTAATAGATTGTTTTGCCACTTAGAATAGCATTTGCCACTTAGTATTTTAAAAAATAATT
  GTTGGAGTATTTATTGTCAGTTTTGTTCACTTGTTATCTAATACAAAATTATAAAGCCTT
  CAGAGGGTTTGGACCACATCTCTTTGGAAAATAGTTTGCAACATATTTAAGAGATACTTG
  ATGCCAAAATGACTTTATACAACGATTGTATTTGTGACTTTTAAAAATAATTATTTTATT
  GTGTAATTGATTTATAAATAACAAAATTTTTTTTACAACTTAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_005242
• Insert Size: 1194 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_005242.3, NP_005233.3
• RefSeq Size: 2876 bp
• RefSeq ORF: 1194 bp
• Locus ID: 2150
• UniProt ID: P55085
• Cytogenetics: 5q13.3
• Domains: 7tm_1
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction
• Gene Summary: This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]