RON (MST1R) (NM_002447) Human Untagged Clone

CAT#: SC309913

MST1R (untagged)-Human macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (MST1R)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RON
• Synonyms: CD136; CDw136; NPCA3; PTK8; RON; SEA
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_002447 edited
  GAATTCGCACCAGTCGGGACCGCTGCTTAAATTTGGCCCAGTCCAGACCTCGAGTCGGGC
  CCCCAGCCAGGCCCACGCCCAGGTCCAGGCCCAGGCCGGTAGGGATCCTCTAGGGTCCCA
  GCTCGCCTCGATGGAGCTCCTCCCGCCGCTGCCTCAGTCCTTCCTGTTGCTGCTGCTGTT
  GCCTGCCAAGCCCGCGGCGGGCGAGGACTGGCAGTGCCCGCGCACCCCCTACGCGGCCTC
  TCGCGACTTTGACGTGAAGTACGTGGTGCCCAGCTTCTCCGCCGGAGGCCTGGTACAGGC
  CATGGTGACCTACGAGGGCGACAGAAATGAGAGTGCTGTGTTTGTAGCCATACGCAATCG
  CCTGCATGTGCTTGGGCCTGACCTGAAGTCTGTCCAGAGCCTGGCCACGGGCCCTGCTGG
  AGACCCTGGCTGCCAGACGTGTGCAGCCTGTGGCCCAGGACCCCACGGCCCTCCCGGTGA
  CACAGACACAAAGGTGCTGGTGCTGGATCCCGCGCTGCCTGCGCTGGTCAGTTGTGGCTC
  CAGCCTGCAGGGCCGCTGCTTCCTGCATGACCTAGAGCCCCAAGGGACAGCCGTGCATCT
  GGCAGCGCCAGCCTGCCTCTTCTCAGCCCACCATAACCGGCCCGATGACTGCCCCGACTG
  TGTGGCCAGCCCATTGGGCACCCGTGTAACTGTGGTTGAGCAAGGCCAGGCCTCCTATTT
  CTACGTGGCATCCTCACTGGACGCAGCCGTGGCTGCCAGCTTCAGCCCACGCTCAGTGTC
  TATCAGGCGTCTCAAGGCTGACGCCTCGGGATTCGCACCGGGCTTTGTGGCGTTGTCAGT
  GCTGCCCAAGCATCTTGTCTCCTACAGTATTGAATACGTGCACAGCTTCCACACGGGAGC
  CTTCGTGTACTTCCTGACTGTACAGCCGGCCAGCGTGACAGATGATCCTAGTGCCCTGCA
  CACACGCCTGGCACGGCTTAGCGCCACTGAGCCAGAGTTGGGTGACTATCGGGAGCTGGT
  CCTCGACTGCAGATTTGCTCCAAAACGCAGGCGCCGGGGGGCCCCAGAAGGCGGACAGCC
  CTACCCTGTGCTGCGGGTGGCCCACTCCGCTCCAGTGGGTGCCCAACTTGCCACTGAGCT
  GAGCATCGCCGAGGGCCAGGAAGTACTATTTGGGGTCTTTGTGACTGGCAAGGATGGTGG
  TCCTGGCGTGGGCCCCAACTCTGTCGTCTGTGCCTTCCCCATTGACCTGCTGGACACACT
  AATTGATGAGGGTGTGGAGCGCTGTTGTGAATCCCCAGTCCATCCAGGCCTCCGGCGAGG
  CCTCGACTTCTTCCAGTCGCCCAGTTTTTGCCCCAACCCGCCTGGCCTGGAAGCCCTCAG
  CCCCAACACCAGCTGCCGCCACTTCCCTCTGCTGGTCAGTAGCAGCTTCTCACGTGTGGA
  CCTATTCAATGGGCTGTTGGGACCAGTACAGGTCACTGCATTGTATGTGACACGCCTTGA
  CAACGTCACAGTGGCACACATGGGCACAATGGATGGGCGTATCCTGCAGGTGGAGCTGGT
  CAGGTCACTAAACTACTTGCTGTATGTGTCCAACTTCTCACTGGGTGACAGTGGGCAGCC
  CGTGCAGCGGGATGTCAGTCGTCTTGGGGACCACCTACTCTTTGCCTCTGGGGACCAGGT
  TTTCCAGGTACCTATCCAAGGCCCTGGCTGCCGCCACTTCCTGACCTGTGGGCGTTGCCT
  AAGGGCATGGCATTTCATGGGCTGTGGCTGGTGTGGGAACATGTGCGGCCAGCAGAAGGA
  GTGTCCTGGCTCCTGGCAACAGGACCACTGCCCACCTAAGCTTACTGAGTTCCACCCCCA
  CAGTGGACCTCTAAGGGGCAGTACAAGGCTGACCCTGTGTGGCTCCAACTTCTACCTTCA
  CCCTTCTGGTCTGGTGCCTGAGGGAACCCATCAGGTCACTGTGGGCCAAAGTCCCTGCCG
  GCCACTGCCCAAGGACAGCTCAAAACTCAGACCAGTGCCCCGGAAAGACTTTGTAGAGGA
  GTTTGAGTGTGAACTGGAGCCCTTGGGCACCCAGGCAGTGGGGCCTACCAACGTCAGCCT
  CACCGTGACTAACATGCCACCGGGCAAGCACTTCCGGGTGGACGGCACCTCCGTGCTGAG
  AGGCTTCTCTTTCATGGAGCCAGTGCTGATAGCAGTGCAACCCCTCTTTGGCCCACGGGC
  AGGAGGCACCTGTCTCACTCTTGAAGGCCAGAGTCTGTCTGTAGGCACCAGCCGGGCTGT
  GCTGGTCAATGGGACTGAGTGTCTGCTAGCACGGGTCAGTGAGGGGCAGCTTTTATGTGC
  CACACCCCCTGGGGCCACGGTGGCCAGTGTCCCCCTTAGCCTGCAGGTGGGGGGTGCCCA
  GGTACCTGGTTCCTGGACCTTCCAGTACAGAGAAGACCCTGTCGTGCTAAGCATCAGCCC
  CAACTGTGGCTACATCAACTCCCACATCACCATCTGTGGCCAGCATCTAACTTCAGCATG
  GCACTTAGTGCTGTCATTCCATGACGGGCTTAGGGCAGTGGAAAGCAGGCAGTGTGAGAG
  GCAGCTTCCAGAGCAGCAGCTGTGCCGCCTTCCTGAATATGTGGTCCGAGACCCCCAGGG
  ATGGGTGGCAGGGAATCTGAGTGCCCGAGGGGATGGAGCTGCTGGCTTTACACTGCCTGG
  CTTTCGCTTCCTACCCCCACCCCATCCACCCAGTGCCAACCTAGTTCCACTGAAGCCTGA
  GGAGCATGCCATTAAGTTTGAGTATATTGGGCTGGGCGCTGTGGCTGACTGTGTGGGTAT
  CAACGTGACCGTGGGTGGTGAGAGCTGCCAGCACGAGTTCCGGGGGGACATGGTTGTCTG
  CCCCCTGCCCCCATCCCTGCAGCTTGGCCAGGATGGTGCCCCATTGCAGGTCTGCGTAGA
  TGGTGAATGTCATATCCTGGGTAGAGTGGTGCGGCCAGGGCCAGATGGGGTCCCACAGAG
  CACGCTCCTTGGTATCCTGCTGCCTTTGCTGCTGCTTGTGGCTGCACTGGCGACTGCACT
  GGTCTTCAGCTACTGGTGGCGGAGGAAGCAGCTAGTTCTTCCTCCCAACCTGAATGACCT
  GGCATCCCTGGACCAGACTGCTGGAGCCACACCCCTGCCTATTCTGTACTCGGGCTCTGA
  CTACAGAAGTGGCCTTGCACTCCCTGCCATTGATGGTCTGGATTCCACCACTTGTGTCCA
  TGGAGCATCCTTCTCCGATAGTGAAGATGAATCCTGTGTGCCACTGCTGCGGAAAGAGTC
  CATCCAGCTAAGGGACCTGGACTCTGCGCTCTTGGCTGAGGTCAAGGATGTGCTGATTCC
  CCATGAGCGGGTGGTCACCCACAGTGACCGAGTCATTGGCAAAGGCCACTTTGGAGTTGT
  CTACCACGGAGAATACATAGACCAGGCCCAGAATCGAATCCAATGTGCCATCAAGTCACT
  AAGTCGCATCACAGAGATGCAGCAGGTGGAGGCCTTCCTGCGAGAGGGGCTGCTCATGCG
  TGGCCTGAACCACCCGAATGTGCTGGCTCTCATTGGTATCATGTTGCCACCTGAGGGCCT
  GCCCCATGTGCTGCTGCCCTATATGTGCCACGGTGACCTGCTCCAGTTCATCCGCTCACC
  TCAGCGGAACCCCACCGTGAAGGACCTCATCAGCTTTGGCCTGCAGGTAGCCCGCGGCAT
  GGAGTACCTGGCAGAGCAGAAGTTTGTGCACAGGGACCTGGCTGCGCGGAACTGCATGCT
  GGACGAGTCATTCACAGTCAAGGTGGCTGACTTTGGTTTGGCCCGCGACATCCTGGACAG
  GGAGTACTATAGTGTTCAACAGCATCGCCACGCTCGCCTACCTGTGAAGTGGATGGCGCT
  GGAGAGCCTGCAGACCTATAGATTTACCACCAAGTCTGATGTGTGGTCATTTGGTGTGCT
  GCTGTGGGAACTGCTGACACGGGGTGCCCCACCATACCGCCACATTGACCCTTTTGACCT
  TACCCACTTCCTGGCCCAGGGTCGGCGCCTGCCCCAGCCTGAGTATTGCCCTGATTCTCT
  GTACCAAGTGATGCAGCAATGCTGGGAGGCAGACCCAGCAGTGCGACCCACCTTCAGAGT
  ACTAGTGGGGGAGGTGGAGCAGATAGTGTCTGCACTGCTTGGGGACCATTATGTGCAGCT
  GCCAGCAACCTACATGAACTTGGGCCCCAGCACCTCGCATGAGATGAATGTGCGTCCAGA
  ACAGCCGCAGTTCTCACCCATGCCAGGGAATGTACGCCGGCCCCGGCCACTCTCAGAGCC
  TCCTCGGCCCACTTGACTTAGTTCTTGGGCTGGACCTGCTTAGCTGCCTTGAGCTAACCC
  CAAGCTGCCTCTGGGCCATGCCAGGCCAGAGGGCAGTGGCCCTCCACCTTGTTCCTGCCC
  TTTAACTTTCAGAGGCAATAGGTAAATGGGGCCCATTAGGTCCCTCACTCCACAGAGTGA
  GCCAGTGAGGGCAGTCCTGCAACATGTATTTATGGAGTGCCTGCTGTGGACCCTGTCTTC
  TGGGCACAGTGGACTCAGCAGTGACCACACCAACACTGACCCTTGAACCAATAAAGGAAC
  AAATGACTATTAAAGCAAAAAAAAAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002447 unedited
  TGACTTCGTNCCGACTGNCAGTTCCGCGCAGCCAGGTCCCTGTGCACAAACTTCTGCTCT
  GCCAGGTACTCCATGCCGCGGGCTACCTGCAGGCCAAAGCTGATGAGGTCCTTCACGGTG
  GGGTTCCGCTGAGGTGAGCGGATGAACTGGAGCAGGTCACCGTGGCACATATAGGGCAGC
  AGCACATGGGGCAGGCCCTCAGGTGGCAACATGATACCAATGAGAGCCAGCACATTCGGG
  TGGTTCAGGCCACGCATGAGCAGCCCCTCTCGCAGGAAGGCCTCCACCTGCTGCATCTCT
  GTGATGCGACTTAGTGACTTGATGGCACATTGGATTCGATTCTGGGCCTGGTCTATGTAT
  TCTCCGTGGTAGACAACTCCAAAGTGGCCTTTGCCAATGACTCGGTCACTGTGGGTGACC
  ACCCGCTCATGGGGAATCAGCACATCCTTGACCTCAGCCAAGAGCGCAGAGTCCAGGTCC
  CTTAGCTGGATGGACTCTTTCCGCAGCAGTGGCACACAGGATTCATCTTCACTATCGGAG
  AAGGATGCTCCATGGACACAAGTGGTGGAATCCAGACCATCAATGGCAGGGAGTGCAAGG
  CCACTTCTGTAGTCAGAGCCCGAGTACAGAATAGGCAGGGGTGTGGCTCCAGCAGTCTGG
  TCCAGGGATGCCAGGTCATTCAGGTTGGGAGGAAGAACTAGCTGCTTNCTCCGCCACCAG
  TAGCTGAAGACCAGTGCAGTCGCCAGTGCAGCCACAAGCAGCAGCAAAGGCAGCAGGATA
  CCAAGGAGCGTGCTCTGTGGGACCCCATCTGGCCCTGGCCGCAC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002447 unedited
  AGNANAGCACTGGGGNAGGGTCACAGGGATGCCACCCGGGATCTGTTCAGGAACAGCTAT
  GACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGCTTTAATAGTCATTT
  GTTCCTTTATTGGTTCAAGGGTCAGTGTTGGTGTGGTCACTGCTGAGTCCACTGTGCCCA
  GAAGACAGGGTCCACAGCAGGCACTCCATAAATACATGTTGCAGGACTGCCCTCACTGGC
  TCACTCTGTGGAGTGAGGGACCTAATGGGCCCCATTTACCTATTGCCTCTGAAAGTTAAA
  GGGCAGGAACAAGGTGGAGGGCCACTGCCCTCTGGCCTGGCATGGCCCAGAGGCAGCTTG
  GGGTTAGCTCAAGGCAGCTAAGCAGGTCCAGCCCAAGAACTAAGTCAAGTGGGCCGAGGA
  GGCTCTGAGAGTGGCCGGGGCCGGCGTACATTCCCTGGCATGGGTGAGAACTGCGGCTGT
  TCTGGACGCACATTCATCTCATGCGAGGTGCTGGGGCCCAAGTTCATGTAGGTTGCTGGC
  AGCTGCACATAATGGTCCCCAAGCAGTGCAGACACTATCTGCTCCACCTCCCCCACTAGT
  ACCTCTGAAGTGGGTCGCACTGCTGGGTCTGCCTCCCAGCATTGCTGCATCACTTGGTAC
  AGAGAATCANGGCAATACTCANGCTGGGGCAGGCGCCGACCCTGGGCCACGAAGTGGGTT
  AGGTCAAAAAGGTCAATGTGCCGGTATGGTGGGGCACCCCGTGTCACCAGTTTCCACAGC
  CACCCCCCAAAAGACCACACATCAGACTTTGTGGGTAAATCTATAAGGGCTGCAGGCTCT
  TCCACGCCG
  
• Restriction Sites: Please inquire
• ACCN: NM_002447
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: There are 5 nucleotide differences between the OriGene clone and the NCBI reference ORF and 1 additional CAG tri-nucleotide repeat, none of which cause any frameshift. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of 3 amino acids and the addition of one glutamine.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002447.1, NP_002438.1
• RefSeq Size: 4785 bp
• RefSeq ORF: 4203 bp
• Locus ID: 4486
• UniProt ID: Q04912
• Cytogenetics: 3p21.31
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
• Gene Summary: This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as isoform Ron).