CD35 (CR1) (NM_000651) Human Untagged Clone

CAT#: SC300114

CR1 (untagged)-Human complement component (3b/4b) receptor 1 (Knops blood group) (CR1), transcript variant S

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CR1
• Synonyms: C3BR; C4BR; CD35; KN
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_000651, the custom clone sequence may differ by one or more nucleotides
  ATGGGGGCCTCTTCTCCAAGAAGCCCGGAGCCTGTCGGGCCGCCGGCGCCCGGTCTCCCC
  TTCTGCTGCGGAGGATCCCTGCTGGCGGTTGTGGTGCTGCTTGCGCTGCCGGTGGCCTGG
  GGTCAATGCAATGCCCCAGAATGGCTTCCATTTGCCAGGCCTACCAACCTAACTGATGAA
  TTTGAGTTTCCCATTGGGACATATCTGAACTATGAATGCCGCCCTGGTTATTCCGGAAGA
  CCGTTTTCTATCATCTGCCTAAAAAACTCAGTCTGGACTGGTGCTAAGGACAGGTGCAGA
  CGTAAATCATGTCGTAATCCTCCAGATCCTGTGAATGGCATGGTGCATGTGATCAAAGGC
  ATCCAGTTCGGATCCCAAATTAAATATTCTTGTACTAAAGGATACCGACTCATTGGTTCC
  TCGTCTGCCACATGCATCATCTCAGGTGATACTGTCATTTGGGATAATGAAACACCTATT
  TGTGACAGAATTCCTTGTGGGCTACCCCCCACCATCACCAATGGAGATTTCATTAGCACC
  AACAGAGAGAATTTTCACTATGGATCAGTGGTGACCTACCGCTGCAATCCTGGAAGCGGA
  GGGAGAAAGGTGTTTGAGCTTGTGGGTGAGCCCTCCATATACTGCACCAGCAATGACGAT
  CAAGTGGGCATCTGGAGCGGCCCCGCCCCTCAGTGCATTATACCTAACAAATGCACGCCT
  CCAAATGTGGAAAATGGAATATTGGTATCTGACAACAGAAGCTTATTTTCCTTAAATGAA
  GTTGTGGAGTTTAGGTGTCAGCCTGGCTTTGTCATGAAAGGACCCCGCCGTGTGAAGTGC
  CAGGCCCTGAACAAATGGGAGCCGGAGCTACCAAGCTGCTCCAGGGTATGTCAGCCACCT
  CCAGATGTCCTGCATGCTGAGCGTACCCAAAGGGACAAGGACAACTTTTCACCTGGGCAG
  GAAGTGTTCTACAGCTGTGAGCCCGGCTACGACCTCAGAGGGGCTGCGTCTATGCGCTGC
  ACACCCCAGGGAGACTGGAGCCCTGCAGCCCCCACATGTGAAGTGAAATCCTGTGATGAC
  TTCATGGGCCAACTTCTTAATGGCCGTGTGCTATTTCCAGTAAATCTCCAGCTTGGAGCA
  AAAGTGGATTTTGTTTGTGATGAAGGATTTCAATTAAAAGGCAGCTCTGCTAGTTACTGT
  GTCTTGGCTGGAATGGAAAGCCTTTGGAATAGCAGTGTTCCAGTGTGTGAACAAATCTTT
  TGTCCAAGTCCTCCAGTTATTCCTAATGGGAGACACACAGGAAAACCTCTGGAAGTCTTT
  CCCTTTGGGAAAACAGTAAATTACACATGCGACCCCCACCCAGACAGAGGGACGAGCTTC
  GACCTCATTGGAGAGAGCACCATCCGCTGCACAAGTGACCCTCAAGGGAATGGGGTTTGG
  AGCAGCCCTGCCCCTCGCTGTGGAATTCTGGGTCACTGTCAAGCCCCAGATCATTTTCTG
  TTTGCCAAGTTGAAAACCCAAACCAATGCATCTGACTTTCCCATTGGGACATCTTTAAAG
  TACGAATGCCGTCCTGAGTACTACGGGAGGCCATTCTCTATCACATGTCTAGATAACCTG
  GTCTGGTCAAGTCCCAAAGATGTCTGTAAACGTAAATCATGTAAAACTCCTCCAGATCCA
  GTGAATGGCATGGTGCATGTGATCACAGACATCCAGGTTGGATCCAGAATCAACTATTCT
  TGTACTACAGGGCACCGACTCATTGGTCACTCATCTGCTGAATGTATCCTCTCGGGCAAT
  GCTGCCCATTGGAGCACGAAGCCGCCAATTTGTCAACGAATTCCTTGTGGGCTACCCCCC
  ACCATCGCCAATGGAGATTTCATTAGCACCAACAGAGAGAATTTTCACTATGGATCAGTG
  GTGACCTACCGCTGCAATCCTGGAAGCGGAGGGAGAAAGGTGTTTGAGCTTGTGGGTGAG
  CCCTCCATATACTGCACCAGCAATGACGATCAAGTGGGCATCTGGAGCGGCCCGGCCCCT
  CAGTGCATTATACCTAACAAATGCACGCCTCCAAATGTGGAAAATGGAATATTGGTATCT
  GACAACAGAAGCTTATTTTCCTTAAATGAAGTTGTGGAGTTTAGGTGTCAGCCTGGCTTT
  GTCATGAAAGGACCCCGCCGTGTGAAGTGCCAGGCCCTGAACAAATGGGAGCCGGAGCTA
  CCAAGCTGCTCCAGGGTATGTCAGCCACCTCCAGATGTCCTGCATGCTGAGCGTACCCAA
  AGGGACAAGGACAACTTTTCACCCGGGCAGGAAGTGTTCTACAGCTGTGAGCCCGGCTAC
  GACCTCAGAGGGGCTGCGTCTATGCGCTGCACACCCCAGGGAGACTGGAGCCCTGCAGCC
  CCCACATGTGAAGTGAAATCCTGTGATGACTTCATGGGCCAACTTCTTAATGGCCGTGTG
  CTATTTCCAGTAAATCTCCAGCTTGGAGCAAAAGTGGATTTTGTTTGTGATGAAGGATTT
  CAATTAAAAGGCAGCTCTGCTAGTTACTGTGTCTTGGCTGGAATGGAAAGCCTTTGGAAT
  AGCAGTGTTCCAGTGTGTGAACAAATCTTTTGTCCAAGTCCTCCAGTTATTCCTAATGGG
  AGACACACAGGAAAACCTCTGGAAGTCTTTCCCTTTGGGAAAACAGTAAATTACACATGC
  GACCCCCACCCAGACAGAGGGACGAGCTTCGACCTCATTGGAGAGAGCACCATCCGCTGC
  ACAAGTGACCCTCAAGGGAATGGGGTTTGGAGCAGCCCTGCCCCTCGCTGTGGAATTCTG
  GGTCACTGTCAAGCCCCAGATCATTTTCTGTTTGCCAAGTTGAAAACCCAAACCAATGCA
  TCTGACTTTCCCATTGGGACATCTTTAAAGTACGAATGCCGTCCTGAGTACTACGGGAGG
  CCATTCTCTATCACATGTCTAGATAACCTGGTCTGGTCAAGTCCCAAAGATGTCTGTAAA
  CGTAAATCATGTAAAACTCCTCCAGATCCAGTGAATGGCATGGTGCATGTGATCACAGAC
  ATCCAGGTTGGATCCAGAATCAACTATTCTTGTACTACAGGGCACCGACTCATTGGTCAC
  TCATCTGCTGAATGTATCCTCTCGGGCAATGCTGCCCATTGGAGCACGAAGCCGCCAATT
  TGTCAACGAATTCCTTGTGGGCTACCCCCCACCATCGCCAATGGAGATTTCATTAGCACC
  AACAGAGAGAATTTTCACTATGGATCAGTGGTGACCTACCGCTGCAATCCTGGAAGCGGA
  GGGAGAAAGGTGTTTGAGCTTGTGGGTGAGCCCTCCATATACTGCACCAGCAATGACGAT
  CAAGTGGGCATCTGGAGCGGCCCGGCCCCTCAGTGCATTATACCTAACAAATGCACGCCT
  CCAAATGTGGAAAATGGAATATTGGTATCTGACAACAGAAGCTTATTTTCCTTAAATGAA
  GTTGTGGAGTTTAGGTGTCAGCCTGGCTTTGTCATGAAAGGACCCCGCCGTGTGAAGTGC
  CAGGCCCTGAACAAATGGGAGCCGGAGCTACCAAGCTGCTCCAGGGTATGTCAGCCACCT
  CCAGATGTCCTGCATGCTGAGCGTACCCAAAGGGACAAGGACAACTTTTCACCCGGGCAG
  GAAGTGTTCTACAGCTGTGAGCCCGGCTATGACCTCAGAGGGGCTGCGTCTATGCGCTGC
  ACACCCCAGGGAGACTGGAGCCCTGCAGCCCCCACATGTGAAGTGAAATCCTGTGATGAC
  TTCATGGGCCAACTTCTTAATGGCCGTGTGCTATTTCCAGTAAATCTCCAGCTTGGAGCA
  AAAGTGGATTTTGTTTGTGATGAAGGATTTCAATTAAAAGGCAGCTCTGCTAGTTATTGT
  GTCTTGGCTGGAATGGAAAGCCTTTGGAATAGCAGTGTTCCAGTGTGTGAACAAATCTTT
  TGTCCAAGTCCTCCAGTTATTCCTAATGGGAGACACACAGGAAAACCTCTGGAAGTCTTT
  CCCTTTGGAAAAGCAGTAAATTACACATGCGACCCCCACCCAGACAGAGGGACGAGCTTC
  GACCTCATTGGAGAGAGCACCATCCGCTGCACAAGTGACCCTCAAGGGAATGGGGTTTGG
  AGCAGCCCTGCCCCTCGCTGTGGAATTCTGGGTCACTGTCAAGCCCCAGATCATTTTCTG
  TTTGCCAAGTTGAAAACCCAAACCAATGCATCTGACTTTCCCATTGGGACATCTTTAAAG
  TACGAATGCCGTCCTGAGTACTACGGGAGGCCATTCTCTATCACATGTCTAGATAACCTG
  GTCTGGTCAAGTCCCAAAGATGTCTGTAAACGTAAATCATGTAAAACTCCTCCAGATCCA
  GTGAATGGCATGGTGCATGTGATCACAGACATCCAGGTTGGATCCAGAATCAACTATTCT
  TGTACTACAGGGCACCGACTCATTGGTCACTCATCTGCTGAATGTATCCTCTCAGGCAAT
  ACTGCCCATTGGAGCACGAAGCCGCCAATTTGTCAACGAATTCCTTGTGGGCTACCCCCA
  ACCATCGCCAATGGAGATTTCATTAGCACCAACAGAGAGAATTTTCACTATGGATCAGTG
  GTGACCTACCGCTGCAATCTTGGAAGCAGAGGGAGAAAGGTGTTTGAGCTTGTGGGTGAG
  CCCTCCATATACTGCACCAGCAATGACGATCAAGTGGGCATCTGGAGCGGCCCCGCCCCT
  CAGTGCATTATACCTAACAAATGCACGCCTCCAAATGTGGAAAATGGAATATTGGTATCT
  GACAACAGAAGCTTATTTTCCTTAAATGAAGTTGTGGAGTTTAGGTGTCAGCCTGGCTTT
  GTCATGAAAGGACCCCGCCGTGTGAAGTGCCAGGCCCTGAACAAATGGGAGCCAGAGTTA
  CCAAGCTGCTCCAGGGTGTGTCAGCCGCCTCCAGAAATCCTGCATGGTGAGCATACCCCA
  AGCCATCAGGACAACTTTTCACCTGGGCAGGAAGTGTTCTACAGCTGTGAGCCTGGCTAT
  GACCTCAGAGGGGCTGCGTCTCTGCACTGCACACCCCAGGGAGACTGGAGCCCTGAAGCC
  CCGAGATGTGCAGTGAAATCCTGTGATGACTTCTTGGGTCAACTCCCTCATGGCCGTGTG
  CTATTTCCACTTAATCTCCAGCTTGGGGCAAAGGTGTCCTTTGTCTGTGATGAAGGGTTT
  CGCTTAAAGGGCAGTTCCGTTAGTCATTGTGTCTTGGTTGGAATGAGAAGCCTTTGGAAT
  AACAGTGTTCCTGTGTGTGAACATATCTTTTGTCCAAATCCTCCAGCTATCCTTAATGGG
  AGACACACAGGAACTCCCTCTGGAGATATTCCCTATGGAAAAGAAATATCTTACACATGT
  GACCCCCACCCAGACAGAGGGATGACCTTCAACCTCATTGGGGAGAGCACCATCCGCTGC
  ACAAGTGACCCTCATGGGAATGGGGTTTGGAGCAGCCCTGCCCCTCGCTGTGAACTTTCT
  GTTCGTGCTGGTCACTGTAAAACCCCAGAGCAGTTTCCATTTGCCAGTCCTACGATCCCA
  ATTAATGACTTTGAGTTTCCAGTCGGGACATCTTTGAATTATGAATGCCGTCCTGGGTAT
  TTTGGGAAAATGTTCTCTATCTCCTGCCTAGAAAACTTGGTCTGGTCAAGTGTTGAAGAC
  AACTGTAGACGAAAATCATGTGGACCTCCACCAGAACCCTTCAATGGAATGGTGCATATA
  AACACAGATACACAGTTTGGATCAACAGTTAATTATTCTTGTAATGAAGGGTTTCGACTC
  ATTGGTTCCCCATCTACTACTTGTCTCGTCTCAGGCAATAATGTCACATGGGATAAGAAG
  GCACCTATTTGTGAGATCATATCTTGTGAGCCACCTCCAACCATATCCAATGGAGACTTC
  TACAGCAACAATAGAACATCTTTTCACAATGGAACGGTGGTAACTTACCAGTGCCACACT
  GGACCAGATGGAGAACAGCTGTTTGAGCTTGTGGGAGAACGGTCAATATATTGCACCAGC
  AAAGATGATCAAGTTGGTGTTTGGAGCAGCCCTCCCCCTCGGTGTATTTCTACTAATAAA
  TGCACAGCTCCAGAAGTTGAAAATGCAATTAGAGTACCAGGAAACAGGAGTTTCTTTACC
  CTCACTGAGATCATCAGATTTAGATGTCAGCCCGGGTTTGTCATGGTAGGGTCCCACACT
  GTGCAGTGCCAGACCAATGGCAGATGGGGGCCCAAGCTGCCACACTGCTCCAGGGTGTGT
  CAGCCGCCTCCAGAAATCCTGCATGGTGAGCATACCCTAAGCCATCAGGACAACTTTTCA
  CCTGGGCAGGAAGTGTTCTACAGCTGTGAGCCCAGCTATGACCTCAGAGGGGCTGCGTCT
  CTGCACTGCACGCCCCAGGGAGACTGGAGCCCTGAAGCCCCTAGATGTACAGTGAAATCC
  TGTGATGACTTCCTGGGCCAACTCCCTCATGGCCGTGTGCTACTTCCACTTAATCTCCAG
  CTTGGGGCAAAGGTGTCCTTTGTTTGCGATGAAGGGTTCCGATTAAAAGGCAGGTCTGCT
  AGTCATTGTGTCTTGGCTGGAATGAAAGCCCTTTGGAATAGCAGTGTTCCAGTGTGTGAA
  CAAATCTTTTGTCCAAATCCTCCAGCTATCCTTAATGGGAGACACACAGGAACTCCCTTT
  GGAGATATTCCCTATGGAAAAGAAATATCTTACGCATGCGACACCCACCCAGACAGAGGG
  ATGACCTTCAACCTCATTGGGGAGAGCTCCATCCGCTGCACAAGTGACCCTCAAGGGAAT
  GGGGTTTGGAGCAGCCCTGCCCCTCGCTGTGAACTTTCTGTTCCTGCTGCCTGCCCACAT
  CCACCCAAGATCCAAAACGGGCATTACATTGGAGGACACGTATCTCTATATCTTCCTGGG
  ATGACAATCAGCTACATTTGTGACCCCGGCTACCTGTTAGTGGGAAAGGGCTTCATTTTC
  TGTACAGACCAGGGAATCTGGAGCCAATTGGATCATTATTGCAAAGAAGTAAATTGTAGC
  TTCCCACTGTTTATGAATGGAATCTCGAAGGAGTTAGAAATGAAAAAAGTATATCACTAT
  GGAGATTATGTGACTTTGAAGTGTGAAGATGGGTATACTCTGGAAGGCAGTCCCTGGAGC
  CAGTGCCAGGCGGATGACAGATGGGACCCTCCTCTGGCCAAATGTACCTCTCGTACACAT
  GATGCTCTCATAGTTGGCACTTTATCTGGTACGATCTTCTTTATTTTACTCATCATTTTC
  CTCTCTTGGATAATTCTAAAGCACAGAAAAGGCAATAATGCACATGAAAACCCTAAAGAA
  GTGGCTATCCATTTACATTCTCAAGGAGGCAGCAGCGTTCATCCCCGAACTCTGCAAACA
  AATGAAGAAAATAGCAGGGTCCTTCCTTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_000651
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000651.3, NP_000642.2
• RefSeq Size: 8814 bp
• RefSeq ORF: 7470 bp
• Locus ID: 1378
• UniProt ID: P17927
• Cytogenetics: 1q32.2
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Complement and coagulation cascades, Hematopoietic cell lineage
• Gene Summary: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020]
  Transcript Variant: This variant (S, also referred to as B) represents the longer transcript and encodes the longer isoform (S, also referred to as isoform CR1-B or CR1*2). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.