Retinoic Acid Receptor alpha (RARA) (NM_000964) Human Untagged Clone

CAT#: SC119566

RARA (untagged)-Human retinoic acid receptor, alpha (RARA), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Retinoic Acid Receptor alpha
• Synonyms: NR1B1; RAR
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119566 sequence for NM_000964 edited (data generated by NextGen Sequencing)
  ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCG
  GTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCT
  CTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCACC
  ATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCT
  CTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTAT
  GGGGTCAGCGCCTGTGAGGGCTGCAAGGGCTTCTTCCGCCGCAGCATCCAGAAGAACATG
  GTGTACACGTGTCACCGGGACAAGAACTGCATCATCAACAAGGTGACCCGGAACCGCTGC
  CAGTACTGCCGACTGCAGAAGTGCTTTGAAGTGGGCATGTCCAAGGAGTCTGTGAGAAAC
  GACCGAAACAAGAAGAAGAAGGAGGTGCCCAAGCCCGAGTGCTCTGAGAGCTACACGCTG
  ACGCCGGAGGTGGGGGAGCTCATTGAGAAGGTGCGCAAAGCGCACCAGGAAACCTTCCCT
  GCCCTCTGCCAGCTGGGCAAATACACTACGAACAACAGCTCAGAACAACGTGTCTCTCTG
  GACATTGACCTCTGGGACAAGTTCAGTGAACTCTCCACCAAGTGCATCATTAAGACTGTG
  GAGTTCGCCAAGCAGCTGCCCGGCTTCACCACCCTCACCATCGCCGACCAGATCACCCTC
  CTCAAGGCTGCCTGCCTGGACATCCTGATCCTGCGGATCTGCACGCGGTACACGCCCGAG
  CAGGACACCATGACCTTCTCGGACGGGCTGACCCTGAACCGGACCCAGATGCACAACGCT
  GGCTTCGGCCCCCTCACCGACCTGGTCTTTGCCTTCGCCAACCAGCTGCTGCCCCTGGAG
  ATGGATGATGCGGAGACGGGGCTGCTCAGCGCCATCTGCCTCATCTGCGGAGACCGCCAG
  GACCTGGAGCAGCCGGACCGGGTGGACATGCTGCAGGAGCCGCTGCTGGAGGCGCTAAAG
  GTCTACGTGCGGAAGCGGAGGCCCAGCCGCCCCCACATGTTCCCCAAGATGCTAATGAAG
  ATTACTGACCTGCGAAGCATCAGCGCCAAGGGGGCTGAGCGGGTGATCACGCTGAAGATG
  GAGATCCCGGGCTCCATGCCGCCTCTCATCCAGGAAATGTTGGAGAACTCAGAGGGCCTG
  GACACTCTGAGCGGACAGCCGGGNNNNNNNNNNNNGGANGGGGGTGGCCTGGCCCCCCCG
  CCAGGCAGCTGTAGCCCCAGCCTCAGCCCCAGCTCCAACAGAAGCAGCCCGGCCACCCAC
  TCCCCGTGA
  
  Clone variation with respect to NM_000964.3
  1284 g=>n;1285 g=>n;1286 g=>n;1287 t=>n;1288 g=>n;1289 g=>n;1290 g=>n;1291 g=>n;1292 g=>n;1293 g=>n;1294 c=>n;1295 g=>n;1299 c=>n
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000964 unedited
  NNCCATGTTCANTATTTGTAAACGACTCATATAGGCGGCCGCGAATCGCACGGGCATAAC
  AGGGGGAATCCTGAATCGGCTGAGAGGCTTCCCCGGTTCTCCTGGGTAACCCCATCGGCC
  CCCTGCCAGCACACACCTGAGCAGCATCACAGGACATGGCCCCCTCAGCCACCGTAGCTG
  GGGACCACATCTAGGAAGATGGACGATCCTTTTTGTGGTGACCCTGGAAGGGCCAGCCTC
  TGAGACCTTGCCCAGGTAAAAGTGCCAGCTCACAGAACTGCTTGACCAAAGGACCGGCTC
  TTGAGACATCCCCCAACCCACCTGGCCCCCAGCTAGGGTGGGGGCTCCAGGAGACTGAGA
  TTAGCCTGCCCTCTTTGGACAGCAGCTCCAGGACAGGGCGGGTGGGCTGACCACCCAAAC
  CCCATCTGGGCCCAGGCCCCATGCCCCGAGGAGGGGTGGTCTGAAGCCCACCAGAGCCCC
  CTGCCAGACTGTCTGCCTCCCTTCTGACTGTGGCCGCTTGGCATGGCCAGCAACAGCAGC
  TCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCGGTGCCTCCCTACGCCTTC
  TTCTTCCCCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCTCTGACCACTCTCCAGCAC
  CAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCACCATTGAGACCCAGAGCAGC
  AGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAG
  CCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTATGGGTTCAGCGCCTGTTGA
  GGCTGCAGGGCTTCTTTCGCCGCAGCATCCAGAAGACATGGTGTACACGTGTCACCGGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000964 unedited
  NGCAGTAGGTGTAATTTTCTATATTAAAATCAAAACAAAAAACATAAAATAAAAACAAAA
  CCAGCGAGAATTAATACCTGGGGTTGGTATGGCAGGGTATGTACAGGGGGAACCCCCCGC
  CCCTGTCCCACCCCCTCTGTCACCAACCGAGGCAGGGGGGAGGTTGAGGTTCCCCAGCTG
  GGGAGCAATGGCTTGTGAGTTCTGAGGATGGGGGAGCCAAGTCCTGGCGTTTGCTGGTGA
  TGAAGATGTGGTGAGCTGGGCAGAGGGGTGTCTTGATGAACACGAGGCCCCCAGGACCCA
  TCCTGAGACCCAGGACCAGGGGCCTCACTCAGTTCCTGGCCTCGGCCTCTGACGTCAGCC
  CATGCTGTGGGAGCAGGCAGTCCACTGAGGGCCCAGGCCTCTGTCCAAGGAGTCGATGCC
  TCCTCCCTCCCCGTCCCCCAGGGAAGGTCCCCAGTACTGCCCGGAAGGGCAGGTGGGGGC
  AGGGCTGGTGCGGGGTTCACACGGTCGGTAGAAAGGCACAAAAAAGCCGGGGCGGACGGC
  GAGGCCTGTGTCCATGCTGCCTGGACGCACACGCGCGAGTGGGTGTCCGAGCTGTTTCAC
  GTTGTACCTTGTTCTCACGTTGTTTCAACTCATGCCCCGCTCCCATTTCCCCTATCCCCC
  TCCCTCCCCCTTTCGCCCTCCTGTCCCCTCGCCGTATTCCTCCCCTCCTACGCCGCCCGC
  CTCACTGCTCATCCTATTTGTGTACTTATCTGTCCGACTTTACCTCCGTACCCTCCAATA
  TCTTTAACCCTTCCTTCTTATCTCCGTAAGTATCTACCGCCACGATCTCCTTTACCTCCC
  CCGTCACTTTTTGTCCTTTCTTTCCGCTTGACCCCTTTGCTCTTCCACGTATCCCGATCT
  CATTTGCTTTTCCCGCATTTACTTCTCCCCCTTT
  
• Restriction Sites: Please inquire
• ACCN: NM_000964
• Insert Size: 2600 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000964.1, NP_000955.1
• RefSeq Size: 2907 bp
• RefSeq ORF: 1389 bp
• Locus ID: 5914
• UniProt ID: P10276
• Cytogenetics: 17q21.2
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Pathways in cancer
• Gene Summary: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
  Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1 and 3 encode the same isoform (1).