Calbindin (CALB1) Mouse Monoclonal Antibody [Clone ID: 5A9]

CAT#: TA388995

Anti-Calbindin Antibody

Specifications

Product Data

• Clone Name: 5A9
• Applications: IHC, WB
• Recommended Dilution: WB: 1:2000
  WB Brain: 1:2000
• Reactivities: Bovine, Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant full length human calbindin purified from E. coli.
• Specificity: Specific for endogenous levels of the ~28 kDa calbindin protein.
• Formulation: PBS + 50% glycerol and 5 mM NaN3
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
• Stability: After date of receipt, stable for at least 1 year at -20°C.
• Predicted Protein Size: 28
• Gene Name: calbindin 1
• Database Link:
  Entrez Gene 793 Human
  UniProt ID P05937
• Background: Calbindin (aka. calbindin D28k) is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. It is predominantly expressed in certain types of neurons, particularly in dendrites and perikarya of the cerebellum and is thought to buffer entry of calcium upon stimulation of glutamate receptors (Andressen et al., 1993). Calbindin has recently been shown to play a critical role in mitochondrial dysfunction and loss of synaptic proteins in vivo in an Alzheimer’s disease mouse model (Kook et al., 2014).
• Synonyms: CAB27; CALB; D-28K
• Note: Protein G purified culture supernatant.