ABCG2 Rabbit Polyclonal Antibody

CAT#: TA383648

ABCG2 Rabbit polyclonal Antibody

Product Images

Western blot analysis of ABCG2 in various lysates using ABCG2 antibody.

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  Western blot analysis of ABCG2 in various lysates using ABCG2 antibody.

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  Western blot analysis of ABCG2 in HT-29 lysates using ABCG2 antibody

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  Western blot analysis of ABCG2 in HT-29 lytsates using ABCG2 antibody.

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  Immunohistochemistry analysis of paraffin-embedded Human brain using ABCG2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Sample with blocking peptide on the right.

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Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 1/500-1/2000
  IHC: 1/100-1/300
  ELISA: 1/10000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against synthesized peptide derived from human ABCG2. AA range:289-338
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Observed MW (kDa):72
• Gene Name: ATP binding cassette subfamily G member 2 (Junior blood group)
• Database Link:
  Entrez Gene 9429 Human
  UniProt ID Q9UNQ0
• Background: Swiss-Prot Acc.Q9UNQ0.High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
• Synonyms: ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; MGC102821; MRX; MXR; MXR1