Perforin (PRF1) Mouse Monoclonal Antibody [Clone ID: 5B10]

CAT#: TA355333

Perforin Mouse Monoclonal Antibody

Product Images

Human follicular lymphoma: immunohistochemical staining for Perforin. Perforin: clone 5B10

Specifications

Product Data

• Clone Name: 5B10
• Applications: IHC
• Recommended Dilution: 1:20
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant prokaryotic protein corresponding to an external region of the C-terminus of the perforin molecule
• Specificity: Human perforin. Shows cross-reactivity with smooth muscle and differentiated epithelium
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: perforin 1
• Database Link:
  Entrez Gene 5551 Human
  UniProt ID P14222
• Background: Perforin is a pore-forming protein found in cytoplasmic granules of cytotoxic T-lymphocytes (CTLs). CTLs bind to cells which express foreign antigens and induce them to lyze. Perforin forms circular lesions on the target cell membrane similar to those induced by complement. Perforin and C9 share a high degree of homology particularly at the membrane spanning region. Perforin is reported to be constitutively expressed in human CD3 negative, CD56 positive NK cells, CD3 positive large granular lymphocytes and gamma/delta T cells. This expression is significantly induced in CD8 positive T cells but to a lesser extent in gamma/delta T cells and NK cells. The induction of perforin mRNA is partially blocked by the immunosuppressive drug cyclosporin A.
• Synonyms: cytolysin; FLH2; HPLH2; MGC65093; OTTHUMP00000019759; P1; PFN1; PFP