p27 KIP 1 (CDKN1B) Rabbit Polyclonal Antibody

CAT#: TA325351

Rabbit Polyclonal p27 Kip1 (Ser10) Antibody (Phospho-specific)

Product Images

Western blot analysis of p27 Kip1 phosphorylation expression in A2780 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against A synthesized peptide derived from human p27 Kip1 around the phosphorylation site of Serine 10
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 27 kDa
• Gene Name: cyclin-dependent kinase inhibitor 1B
• Database Link:
  NP_004055
  Entrez Gene 12576 MouseEntrez Gene 83571 RatEntrez Gene 1027 Human
  UniProt ID P46527
• Background: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1.
• Synonyms: CDKN4; KIP1; MEN1B; MEN4; P27KIP1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer