CLDN19 Rabbit Polyclonal Antibody

CAT#: TA322029

Anti-CLDN19 Rabbit Polyclonal Antibody

Product Images

Gel: 12%SDS-PAGE Lysate: 40 μg Lane 1-2: Hepg2 and 293T cell Primary antibody: TA322029 (CLDN19 Antibody) at dilution 1/200 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 5 seconds

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322029 (CLDN19 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322029 (CLDN19 Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Hepg2 and 293T cell
  IHC: 10-50
  Positive control: Human liver cancer
  Predicted cell location: Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 186-200 amino acids of Human Claudin 19
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 23 kDa
• Gene Name: claudin 19
• Database Link:
  NP_683763
  Entrez Gene 242653 MouseEntrez Gene 298487 RatEntrez Gene 149461 Human
  UniProt ID Q8N6F1
• Background: The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space; through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia; hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars; macular colobomata; significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
• Synonyms: HOMG5

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction