Ubiquilin (UBQLN1) Rabbit Polyclonal Antibody

CAT#: TA308768

Rabbit polyclonal antibody to Ubiquilin-1 (ubiquilin 1)

Product Images

Sample (30 ug of whole cell lysate). A: 293T. 7.5% SDS PAGE. TA308768 diluted at 1:1000.

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  Immunofluorescence analysis of paraformaldehyde-fixed A549, using Ubiquilin-1 (TA308768) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human (Predicted: Mouse, Rat, Bovine)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 64 and 345 of Ubiquilin-1 (Uniprot ID#Q9UMX0)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 63 kDa
• Gene Name: ubiquilin 1
• Database Link:
  NP_444295
  Entrez Gene 56085 MouseEntrez Gene 114590 RatEntrez Gene 29979 Human
  UniProt ID Q9UMX0
• Background: This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
• Synonyms: DA41; DSK2; PLIC-1; UBQN; XDRP1
• Note: Seq homology of immunogen across species: Mouse (90%), Rat (90%), Bovine (95%)

Reference Data

• Protein Families: Druggable Genome