JMJD6 Rabbit Polyclonal Antibody

CAT#: TA306835

Rabbit Polyclonal JMJD6 Antibody

Product Images

Western blot analysis of JMJD6 in human brain tissue lysate with JMJD6 antibody at (A) 1 and (B) 2 ug/ml.

• 

  Immunohistochemistry of JMJD6 in rat brain tissue with JMJD6 antibody at 2.5 ug/ml.

• 

  Immunofluorescence of JMJD6 in rat brain tissue with JMJD6 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: JMJD6 antibody was raised against a 15 amino acid peptide from near the amino terminus of human JMJD6.
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: arginine demethylase and lysine hydroxylase
• Database Link:
  NP_001074930
  Entrez Gene 107817 MouseEntrez Gene 360665 RatEntrez Gene 23210 Human
  UniProt ID Q6NYC1
• Background: The jumonji domain-containing protein (JMJD) family is defined by the presence of the JmjC domain that is observed in several diverse species. JMJD6 was initially identified as a membrane protein that participates in phagocytosis but recent studies have shown that it has other functions when it is expressed in the cytosol and nucleus. JMJD6 is thought to play important roles in regulation of development and differentiation as knockdown experiments in mice resulted in neonatal lethality with severe defects in the morphology of numerous organs. JMJD6 also can catalyze the lysyl-hydroxylation of U2AF65, a protein involved with RNA splicing, suggesting that some of the functions attributed to JMJD6 may be due to its regulatory activity of RNA splicing.
• Synonyms: PSR; PTDSR; PTDSR1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS