LFA3 (CD58) Mouse Monoclonal Antibody [Clone ID: MEM-63]

CAT#: SM3032B

LFA3 (CD58) mouse monoclonal antibody, clone MEM-63, Biotin

Product Images

Surface staining of human peripheral blood cells with anti-CD58 (MEM-63) biotin / streptavidin-PE.

Specifications

Product Data

• Clone Name: MEM-63
• Applications: FC
• Recommended Dilution: Flow Cytometry: 1:200 as starting point.
• Reactivities: Human, Porcine
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: NALM-6 human pre-B cell line
• Specificity: This antibody reacts with CD58 (LFA-3), a 40-70 kDa glycoprotein distributed over many tissues, leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts.
• Formulation: Phosphate buffered saline (PBS)
  Label: Biotin
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide, approx. pH 8.0
  Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
• Concentration: lot specific
• Conjugation: Biotin
• Storage:

  Store undiluted at 2-8°C.
  DO NOT FREEZE!
  

• Stability: Shelf life: one year from despatch.

• Gene Name: CD58 molecule
• Database Link:
  Entrez Gene 965 Human
  UniProt ID P19256
• Background: CD58 (LFA-3) is an immunoglobulin family adhession molecule expressed by both hematopoietic and non-hematopoietic cells (often on antigen presenting cells) and serving as ligand of CD2. This interaction is important for T cell-mediated immunity. CD58 is expressed in transmembrane form and in GPI-anchored form; the later is constitutively associated with protein kinases whereas the transmembrane form activates kinase activity upon triggering. CD58 is a powerful tool for detection of minimal residual disease in acute lymphocytic leukemia, and for evaluation of liver damage related with hepatitis B.
• Synonyms: Ag3, LFA-3