DCC (Center) Rabbit Polyclonal Antibody

CAT#: AP51195PU-N

DCC (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Netrin receptor DCC Antibody in Mouse heart tissue lysates (35ug/lane). This demonstrates the DCC antibody detected the DCC protein (arrow).

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  Formalin fixed and paraffin embedded human stomach tissue stained with Netrin receptor DCC Antibody followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 642-670 amino acids from the Central region of Human DCC.
• Specificity: This antibody recognizes Human and Mouse DCC (Center).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: DCC netrin 1 receptor
• Database Link:
  Entrez Gene 13176 MouseEntrez Gene 1630 Human
  UniProt ID P43146
• Background:
  This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
• Synonyms: IGDCC1, Tumor suppressor protein DCC, Colorectal cancer suppressor, CRC18, CRCR1
• Note: Molecular Weight: 158457 Da

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Axon guidance, Colorectal cancer, Pathways in cancer