FPR1 Rabbit Polyclonal Antibody

CAT#: AP23634PU-N

FPR1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from K562 cells, using FPR1 Antibody. The lane on the right is treated with the synthesized peptide.

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence analysis of MCF7 cells, using FPR1 Antibody. The picture on the right is treated with the synthesized peptide.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Immunofluorescence: 1/100 - 1/500.
  Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between aa 155 -204 of human FPR1.
• Specificity: FPR1 Antibody detects endogenous levels of total FPR1 protein.
• Formulation: PBS (without Mg²⁺, Ca²⁺), pH 7.4 containing 150 mM Sodium Chloride
  State: Aff - Purified
  State: Liquid purfied Ig fraction
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: formyl peptide receptor 1
• Database Link:
  Entrez Gene 2357 Human
  UniProt ID P21462
• Background: Formyl peptide receptor 1, a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FPR1, attract polymorphonuclear neutrophils to sites of infection. FPR receptors promote the phosphorylation and downregulation of CCR5, which has been shown to inhibit HIV infection. Therefore, ligands for an FPR receptor may be able to inhibit HIV infection.
• Synonyms: N-formyl peptide receptor, FPR1

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction