RAI3 (GPRC5A) Rabbit Polyclonal Antibody

CAT#: AP01430PU-N

RAI3 (GPRC5A) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of RAI3 antibody (Cat.-No.: AP01430PU-N) in extracts from LOVO cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: RAI3 antibody detects endogenous levels of RAI3 protein. (region surrounding Leu179)
• Formulation: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 42 kDa
• Gene Name: G protein-coupled receptor class C group 5 member A
• Database Link:
  Entrez Gene 9052 Human
  UniProt ID Q8NFJ5
• Background: Retinoic acid-induced protein 3 (RAI3) is a transmembrane G protein-coupled receptor that affects many essential biological processes including embryogenesis,cell growth, differentiation and apoptosis. RAI3 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate RAI3 during its transcription in embryonal carcinoma differentiation. RAI3 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of RAI3 and represses its expression at the beginning of apoptosis. RAI3 is a potential molecular target for diagnosing breast cancer; selective suppression of signals from RAI3 may have a place in breast cancer treatments.
• Synonyms: Retinoic acid-induced protein 3, G-protein coupled receptor C5A, PEIG-1, RAIG1, GPCR5A