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- MEK1 (34)
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- NM23A (28)
- KI67 (26)
- CYTOKERATIN 19 (25)
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- KALLIKREIN 8 (23)
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- P95 NBS1 (21)
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- P GLYCOPROTEIN (17)
- P16INK4A (17)
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- GALECTIN 3 (16)
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- VILIP1 (15)
- BETA CATENIN (14)
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- CYTOKERATIN 20 (13)
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- THYMIDINE PHOSPHORYLASE (12)
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- BBOX1 (11)
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- ALDH1L1 (10)
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- CD117 (10)
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- E CADHERIN (10)
- GBP2 (10)
- LEUKOTRIENE A4 HYDROLASE (10)
- MCM2 (10)
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- MONOACYLGLYCEROL LIPASE (10)
- NATRIURETIC PEPTIDE RECEPTOR C (10)
- PARVIN ALPHA (10)
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- THYMIDYLATE SYNTHASE (10)
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- SQSTM1 (9)
- SYNAPTOPHYSIN (9)
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- TTC32 (9)
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Knockout (KO) Validation
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- Druggable Genome (3398)
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- Secreted Protein (529)
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- Induced pluripotent stem cells (34)
- Stem cell relevant signaling - DSL/Notch pathway (34)
- Stem cell relevant signaling - JAK/STAT signaling pathway (24)
- Ion Channels: Other (18)
- GPCR (13)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (12)
- Stem cell relevant signaling - Wnt Signaling pathway (4)
- Ion Channels: Cys-loop Receptors (3)
- Ion Channels: Transient receptor potential (3)
- Ion Channels: Potassium (2)
Pathways
- Metabolic pathways (697)
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- MAPK signaling pathway (237)
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- Prostate cancer (224)
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- T cell receptor signaling pathway (187)
- Cell adhesion molecules (CAMs) (185)
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- Endometrial cancer (177)
- Bladder cancer (176)
- Pancreatic cancer (175)
- Toll-like receptor signaling pathway (175)
- ErbB signaling pathway (173)
- Glioma (168)
- Non-small cell lung cancer (168)
- Chronic myeloid leukemia (164)
- B cell receptor signaling pathway (162)
- Hematopoietic cell lineage (155)
- Insulin signaling pathway (148)
- Progesterone-mediated oocyte maturation (147)
- Regulation of actin cytoskeleton (147)
- Fc epsilon RI signaling pathway (141)
- Acute myeloid leukemia (133)
- Fc gamma R-mediated phagocytosis (132)
- Cell cycle (131)
- Renal cell carcinoma (128)
- Apoptosis (123)
- Thyroid cancer (117)
- Leukocyte transendothelial migration (115)
- Natural killer cell mediated cytotoxicity (111)
- GnRH signaling pathway (109)
- Chemokine signaling pathway (106)
- Pyrimidine metabolism (105)
- Purine metabolism (104)
- Wnt signaling pathway (103)
- Cytokine-cytokine receptor interaction (102)
- VEGF signaling pathway (102)
- Small cell lung cancer (101)
- p53 signaling pathway (101)
- Endocytosis (96)
- Jak-STAT signaling pathway (95)
- Melanogenesis (95)
- Alzheimer's disease (94)
- Oocyte meiosis (92)
- Amyotrophic lateral sclerosis (ALS) (91)
- Adherens junction (87)
- Gap junction (87)
- Huntington's disease (80)
- Type II diabetes mellitus (79)
- Primary immunodeficiency (76)
- Arginine and proline metabolism (72)
- Glycolysis / Gluconeogenesis (71)
- Prion diseases (69)
- mTOR signaling pathway (69)
- Adipocytokine signaling pathway (67)
- Pathogenic Escherichia coli infection (66)
- Ubiquitin mediated proteolysis (65)
- Complement and coagulation cascades (64)
- Long-term depression (64)
- Vascular smooth muscle contraction (64)
- Lysosome (62)
- Long-term potentiation (61)
- Parkinson's disease (61)
- Valine (61)
- leucine and isoleucine degradation (61)
- Basal cell carcinoma (59)
- Glycerolipid metabolism (58)
- Calcium signaling pathway (56)
- Nucleotide excision repair (56)
- Antigen processing and presentation (52)
- Dorso-ventral axis formation (51)
- Epithelial cell signaling in Helicobacter pylori infection (50)
- Drug metabolism - cytochrome P450 (48)
- Fatty acid metabolism (48)
- Phosphatidylinositol signaling system (48)
- Systemic lupus erythematosus (48)
- Tight junction (48)
- Metabolism of xenobiotics by cytochrome P450 (47)
- Oxidative phosphorylation (46)
- Tryptophan metabolism (46)
- Autoimmune thyroid disease (45)
- Axon guidance (45)
- Lysine degradation (45)
- Arachidonic acid metabolism (43)
- ECM-receptor interaction (42)
- Propanoate metabolism (42)
- Alanine (41)
- DNA replication (41)
- Inositol phosphate metabolism (41)
- aspartate and glutamate metabolism (41)
- Butanoate metabolism (40)
- Dilated cardiomyopathy (40)
- PPAR signaling pathway (40)
- Mismatch repair (39)
- RIG-I-like receptor signaling pathway (39)
- Hypertrophic cardiomyopathy (HCM) (38)
- RNA degradation (37)
- Glutathione metabolism (36)
- TGF-beta signaling pathway (36)
- Cytosolic DNA-sensing pathway (35)
- Base excision repair (34)
- One carbon pool by folate (34)
- Spliceosome (34)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (33)
- Histidine metabolism (32)
- Retinol metabolism (32)
- Tyrosine metabolism (32)
- Glycine (31)
- Pyruvate metabolism (31)
- serine and threonine metabolism (31)
- Renin-angiotensin system (30)
- Type I diabetes mellitus (29)
- Viral myocarditis (29)
- Homologous recombination (28)
- beta-Alanine metabolism (28)
- Proteasome (27)
- NOD-like receptor signaling pathway (26)
- Pentose phosphate pathway (25)
- ABC transporters (24)
- Allograft rejection (24)
- Cardiac muscle contraction (23)
- Drug metabolism - other enzymes (23)
- Amino sugar and nucleotide sugar metabolism (22)
- Hedgehog signaling pathway (22)
- Starch and sucrose metabolism (22)
- Linoleic acid metabolism (21)
- Circadian rhythm - mammal (20)
- Cysteine and methionine metabolism (20)
- Fructose and mannose metabolism (19)
- Neuroactive ligand-receptor interaction (19)
- Notch signaling pathway (19)
- Terpenoid backbone biosynthesis (19)
- Vibrio cholerae infection (19)
- Fatty acid elongation in mitochondria (18)
- Graft-versus-host disease (18)
- Nicotinate and nicotinamide metabolism (18)
- Sulfur metabolism (17)
- Nitrogen metabolism (16)
- Primary bile acid biosynthesis (16)
- Aminoacyl-tRNA biosynthesis (15)
- Caffeine metabolism (15)
- Citrate cycle (TCA cycle) (15)
- Folate biosynthesis (15)
- Galactose metabolism (15)
- Sphingolipid metabolism (14)
- Maturity onset diabetes of the young (13)
- N-Glycan biosynthesis (13)
- Asthma (12)
- SNARE interactions in vesicular transport (12)
- Synthesis and degradation of ketone bodies (12)
- Glycerophospholipid metabolism (11)
- Other glycan degradation (11)
- RNA polymerase (10)
- Regulation of autophagy (10)
- Methane metabolism (9)
- Porphyrin and chlorophyll metabolism (9)
- Selenoamino acid metabolism (9)
- Glyoxylate and dicarboxylate metabolism (8)
- Non-homologous end-joining (8)
- Ribosome (8)
- Taste transduction (7)
- Cyanoamino acid metabolism (6)
- Glycosaminoglycan degradation (6)
- Androgen and estrogen metabolism (5)
- Ascorbate and aldarate metabolism (5)
- Pantothenate and CoA biosynthesis (5)
- Phenylalanine metabolism (5)
- Biosynthesis of unsaturated fatty acids (4)
- Fatty acid biosynthesis (4)
- Limonene and pinene degradation (4)
- Steroid biosynthesis (4)
- Vitamin B6 metabolism (4)
- Ether lipid metabolism (3)
- Glycosphingolipid biosynthesis - ganglio series (3)
- Olfactory transduction (3)
- Pentose and glucuronate interconversions (3)
- Taurine and hypotaurine metabolism (3)
- D-Glutamine and D-glutamate metabolism (2)
- Glycosphingolipid biosynthesis - lacto and neolacto series (2)
- Keratan sulfate biosynthesis (2)
- O-Glycan biosynthesis (2)
- Riboflavin metabolism (2)
- Thiamine metabolism (2)
- Basal transcription factors (1)
- Biotin metabolism (1)
- C21-Steroid hormone metabolism (1)
- Glycosphingolipid biosynthesis - globo series (1)
- Protein export (1)
- leucine and isoleucine biosynthesis (1)