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Antibodies
Anti-Dendra2 rabbit polyclonal antibody
| Applications | WB |
| Conjugation | Unconjugated |
| Immunogen | Purified Dendra2 protein expressed in E. coli. |
PGK1 rabbit polyclonal antibody, Azide Free
| Applications | ELISA, ID, IF, IP, R, WB |
| Reactivities | Bakers Yeast |
| Conjugation | Unconjugated |
| Immunogen | 3-Phosphoglyceric Phosphokinase isolated and purified from baker's yeast. Freund’s complete adjuvant is used in the first step of the immunization procedure. |
Rabbit polyclonal anti-TUBB(beta Tubulin) antibody, Loading control
| Applications | ICC/IF, IHC, Simple Western, WB |
| Reactivities | Human, Mouse, Chicken, Xenopus, Porcine, Zebrafish, Hamster, Rat |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide made to the N-terminal region of human beta tubulin (within residues 1-100). Swiss-Prot P07437. |
PROX1 (C-term) rabbit polyclonal antibody, Aff - Purified
| Applications | ELISA, IF, IHC, WB |
| Reactivities | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Immunogen | Recombinant Human C-terminal part of the Homeobox Transcription Factor Prox-1 (homeo domain and prospero domain). (Cat.-No DA3565) |
Rabbit Polyclonal OCLN Antibody
| Applications | IF, IHC, WB |
| Reactivities | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Immunogen | OCLN antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human OCLN. The immunogen is located within the last 50 amino acids of OCLN. |
Rabbit Polyclonal PD-L1 Antibody
| Applications | FC, IF, IHC, WB |
| Reactivities | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Immunogen | PD-L1 antibody was raised against a 17 amino acid synthetic peptide from near the center of human PD-L1. The immunogen is located within amino acids 60 - 110 of PD-L1. |
Anti-SLC16A1 Rabbit Polyclonal Antibody
| Applications | IHC, WB |
| Reactivities | Human |
| Conjugation | Unconjugated |
| Immunogen | Synthetic peptide corresponding to a region derived from 484-500 amino acids of Human solute carrier family 16, member 1 (monocarboxylic acid transporter 1) |
Rabbit Polyclonal FALDH Antibody
| Applications | ELISA, IF, IHC, WB |
| Reactivities | Human |
| Conjugation | Unconjugated |
| Immunogen | DNA immunization. This antibody is specific for the N Terminus Region of the target protein. |
Rabbit polyclonal SLC11A2 Antibody (Center)
| Applications | IF, WB |
| Reactivities | Mouse |
| Conjugation | Unconjugated |
| Immunogen | This SLC11A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-291 amino acids from the Central region of human SLC11A2. |
Collagen II (COL2A1) rabbit polyclonal antibody, Aff - Purified
| Applications | ELISA, IHC, IP, WB |
| Reactivities | Bovine, Human, Mouse, Rat, Sheep |
| Conjugation | Unconjugated |
| Immunogen | Collagen type II purified from Human knee and Bovine nasal cartilage. |
Rabbit Polyclonal Antibody against LC3
| Applications | ChIP, ELISA, FC, ICC/IF, IHC, Immunoblotting, IP, Simple Western, WB |
| Reactivities | Human, Rat, Mouse |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide made to an internal portion of the human LC3 protein sequence (between residues 25-121). |
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Knockout (KO) Validation
Modifications
- Unmodified (7199)
- Phospho-specific (1152)
- Acetyl K5 (4)
- Phospho S83 (4)
- Phospho S376 (3)
- Acetyl K12 (2)
- Acetyl K16 (2)
- Acetyl K27 (2)
- Acetyl K36 (2)
- Acetyl K4 (2)
- Phospho S104 (2)
- Phospho S129 (2)
- Phospho S139 (2)
- Phospho S15 (2)
- Phospho S16 (2)
- Phospho S166 (2)
- Phospho S21 (2)
- Phospho S319 (2)
- Phospho S380 (2)
- Phospho S396 (2)
- Phospho S727 (2)
- Phospho S9 (2)
- Phospho T286 (2)
- Phospho T389 (2)
- Phospho T514 (2)
- Phospho Y410 (2)
- Phospho Y779 (2)
- TriMethyl K56 (2)
- Acetyl K14 (1)
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- Acetyl K23 (1)
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- Acetyl K332 (1)
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- Acetyl K8 (1)
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- Acetyl K9/K14/K18/K23/K27 (1)
- Acetyl K91 (1)
- Asymmetric DiMethyl R3 (1)
- K11-linkage Specific Polyubiquitin (1)
- K27-linkage Specific Polyubiquitin (1)
- K29-linkage Specific Polyubiquitin (1)
- K33-linkage Specific Polyubiquitin (1)
- K48-linkage Specific Polyubiquitin (1)
- K6-linkage Specific Polyubiquitin (1)
- M1-linkage Specific Polyubiquitin (1)
- MonoMethyl K342 (1)
- MonoMethyl K36 (1)
- MonoMethyl K5 (1)
- Pan Acetyl-Lysine (1)
- Pan DiMethyl-lysine (1)
- Pan Phospho-Tyrosine (1)
- Phospho 180/Y182,Phospho T180/Y182,Phospho T180/Y182,Phospho T183/Y1845 (1)
- Phospho Phospho S87 (1)
- Phospho S1 (1)
- Phospho S10 (1)
- Phospho S10/T11 (1)
- Phospho S1033 (1)
- Phospho S11 (1)
- Phospho S1105 (1)
- Phospho S1108 (1)
- Phospho S1177 (1)
- Phospho S1248 (1)
- Phospho S127 (1)
- Phospho S128 (1)
- Phospho S1387 (1)
- Phospho S1490 (1)
- Phospho S157 (1)
- Phospho S16/T17 (1)
- Phospho S172 (1)
- Phospho S176 (1)
- Phospho S176/180 (1)
- Phospho S180 (1)
- Phospho S182 (1)
- Phospho S189,Phospho S207 (1)
- Phospho S19 (1)
- Phospho S194 (1)
- Phospho S1943 (1)
- Phospho S1981 (1)
- Phospho S2 (1)
- Phospho S20 (1)
- Phospho S2056 (1)
- Phospho S209 (1)
- Phospho S211 (1)
- Phospho S2152 (1)
- Phospho S22 (1)
- Phospho S235/236 (1)
- Phospho S240/244 (1)
- Phospho S241 (1)
- Phospho S243 (1)
- Phospho S2481 (1)
- Phospho S253 (1)
- Phospho S257/T261 (1)
- Phospho S259 (1)
- Phospho S271 (1)
- Phospho S28 (1)
- Phospho S280 (1)
- Phospho S29/33/37/T41 (1)
- Phospho S293 (1)
- Phospho S294 (1)
- Phospho S298 (1)
- Phospho S307 (1)
- Phospho S308,Phospho S309,Phospho S305 (1)
- Phospho S32 (1)
- Phospho S32/S36 (1)
- Phospho S33 (1)
- Phospho S330 (1)
- Phospho S334 (1)
- Phospho S338 (1)
- Phospho S345 (1)
- Phospho S358 (1)
- Phospho S36 (1)
- Phospho S366 (1)
- Phospho S37 (1)
- Phospho S39 (1)
- Phospho S392 (1)
- Phospho S397 (1)
- Phospho S40 (1)
- Phospho S409/S410 (1)
- Phospho S412 (1)
- Phospho S420 (1)
- Phospho S422 (1)
- Phospho S423/S425 (1)
- Phospho S425 (1)
- Phospho S428 (1)
- Phospho S445 (1)
- Phospho S448 (1)
- Phospho S45 (1)
- Phospho S455 (1)
- Phospho S46 (1)
- Phospho S465/467 + S423/425 (1)
- Phospho S465/S467 (1)
- Phospho S467 (1)
- Phospho S471/472 (1)
- Phospho S473 (1)
- Phospho S473,Phospho S474,Phospho S472 (1)
- Phospho S474 (1)
- Phospho S483 (1)
- Phospho S485 (1)
- Phospho S5 (1)
- Phospho S505 (1)
- Phospho S507 (1)
- Phospho S51 (1)
- Phospho S516 (1)
- Phospho S519/T522 (1)
- Phospho S529 (1)
- Phospho S552 (1)
- Phospho S555 (1)
- Phospho S56 (1)
- Phospho S563 (1)
- Phospho S588 (1)
- Phospho S6 (1)
- Phospho S608 (1)
- Phospho S611/615 (1)
- Phospho S611/615/616 (1)
- Phospho S616 (1)
- Phospho S62 (1)
- Phospho S621 (1)
- Phospho S63 (1)
- Phospho S636/639 (1)
- Phospho S638 (1)
- Phospho S641 (1)
- Phospho S643/676 (1)
- Phospho S645 (1)
- Phospho S65 (1)
- Phospho S657/Y658 (1)
- Phospho S668 (1)
- Phospho S675 (1)
- Phospho S7 (1)
- Phospho S70 (1)
- Phospho S71 (1)
- Phospho S728 (1)
- Phospho S73 (1)
- Phospho S744/748 (1)
- Phospho S757 (1)
- Phospho S795 (1)
- Phospho S807/811 (1)
- Phospho S811 (1)
- Phospho S838/S840 (1)
- Phospho S886 (1)
- Phospho S89 (1)
- Phospho S890 (1)
- Phospho S896/S897 (1)
- Phospho S897 (1)
- Phospho S916 (1)
- Phospho S957 (1)
- Phospho S967 (1)
- Phospho Ser15 (1)
- Phospho Ser404 (1)
- Phospho Ser416 (1)
- Phospho Ser792 (1)
- Phospho Ser90 (1)
- Phospho T11 (1)
- Phospho T117 (1)
- Phospho T14 (1)
- Phospho T1462 (1)
- Phospho T156 (1)
- Phospho T163 (1)
- Phospho T17 (1)
- Phospho T172 (1)
- Phospho T179 (1)
- Phospho T18/S19 (1)
- Phospho T180/T183 (1)
- Phospho T180/Y182 (1)
- Phospho T180/Y182 + T183/Y1845 (1)
- Phospho T181 (1)
- Phospho T183/T172 (1)
- Phospho T183/Y185 (1)
- Phospho T183/Y185,Phospho T221/Y223 (1)
- Phospho T186 (1)
- Phospho T187 (1)
- Phospho T189 (1)
- Phospho T197 (1)
- Phospho T1989 (1)
- Phospho T199 (1)
- Phospho T202/Y204 + T185/Y187 (1)
- Phospho T202/Y204+T185/Y187 (1)
- Phospho T204 (1)
- Phospho T217 (1)
- Phospho T231 (1)
- Phospho T231/S232 (1)
- Phospho T232 (1)
- Phospho T235 (1)
- Phospho T24,Phospho T32,Phospho T28 (1)
- Phospho T246 (1)
- Phospho T261 (1)
- Phospho T288 (1)
- Phospho T288,Phospho T232,Phospho T198 (1)
- Phospho T292 (1)
- Phospho T3 (1)
- Phospho T308 (1)
- Phospho T32 (1)
- Phospho T320 (1)
- Phospho T334 (1)
- Phospho T346 (1)
- Phospho T357/S358/S360 (1)
- Phospho T359 (1)
- Phospho T359/S363 (1)
- Phospho T37/46 (1)
- Phospho T384 (1)
- Phospho T387 (1)
- Phospho T395 (1)
- Phospho T410 (1)
- Phospho T421/S424 (1)
- Phospho T434 (1)
- Phospho T446 (1)
- Phospho T45 (1)
- Phospho T495 (1)
- Phospho T498 (1)
- Phospho T505 (1)
- Phospho T538 (1)
- Phospho T56 (1)
- Phospho T567,Phospho T564,Phospho T558 (1)
- Phospho T58 (1)
- Phospho T642 (1)
- Phospho T668 (1)
- Phospho T669 (1)
- Phospho T678 (1)
- Phospho T69/71 (1)
- Phospho T69/T71 (1)
- Phospho T696 (1)
- Phospho T70 (1)
- Phospho T81 (1)
- Phospho T853 (1)
- Phospho T91 (1)
- Phospho T918 (1)
- Phospho T93 (1)
- Phospho T982 (1)
- Phospho Thr212/Ser214 (1)
- Phospho Y10 (1)
- Phospho Y1007 (1)
- Phospho Y1007/1008 (1)
- Phospho Y1008 (1)
- Phospho Y1020 (1)
- Phospho Y1021 (1)
- Phospho Y1022/1023 (1)
- Phospho Y1045 (1)
- Phospho Y1054/1055 (1)
- Phospho Y1068 (1)
- Phospho Y1086 (1)
- Phospho Y1096 (1)
- Phospho Y1148 (1)
- Phospho Y1173 (1)
- Phospho Y1175 (1)
- Phospho Y1217 (1)
- Phospho Y1221/1222 (1)
- Phospho Y1234/1235 (1)
- Phospho Y1284 (1)
- Phospho Y133 (1)
- Phospho Y1349 (1)
- Phospho Y14 (1)
- Phospho Y145 (1)
- Phospho Y1474 (1)
- Phospho Y15 (1)
- Phospho Y165 (1)
- Phospho Y171 (1)
- Phospho Y177 (1)
- Phospho Y182 (1)
- Phospho Y191 (1)
- Phospho Y207 (1)
- Phospho Y216 (1)
- Phospho Y221 (1)
- Phospho Y245 (1)
- Phospho Y284 (1)
- Phospho Y307 (1)
- Phospho Y311 (1)
- Phospho Y340 (1)
- Phospho Y353 (1)
- Phospho Y412 (1)
- Phospho Y416 (1)
- Phospho Y416/Y416 (1)
- Phospho Y467/Y199/Y464 (1)
- Phospho Y564 (1)
- Phospho Y576/577 (1)
- Phospho Y589/591 (1)
- Phospho Y594 (1)
- Phospho Y653 (1)
- Phospho Y659 (1)
- Phospho Y674/675 + Y706/707 (1)
- Phospho Y694 (1)
- Phospho Y700 (1)
- Phospho Y705 (1)
- Phospho Y708 (1)
- Phospho Y719 (1)
- Phospho Y724 (1)
- Phospho Y751 (1)
- Phospho Y754 (1)
- Phospho Y759 (1)
- Phospho Y771 (1)
- Phospho Y789 (1)
- Phospho Y792 (1)
- Phospho Y845 (1)
- Phospho Y849 (1)
- Phospho Y869 (1)
- Phospho Y925 (1)
- Phospho Y980/981 (1)
- Phospho Y992 (1)
- Phospho Y996 (1)
- Phospho Y998 (1)
- Phospho pS221 (1)
- Phospho-(Ser/Thr) (1)
- Phospho-PKC (pan) (βII Ser660) (1)
- Phospho-RPS6KB1-S371 (1)
- Ubiquityl K119 (1)
- Unconjugated (1)
- citrulline R2/R8/R17 (1)
- monoMethyl E105 (1)
- pan Phospho-Serine/Threonine (1)
- pan Symmetric-DiMethyl-Arginine (1)
- pan-Di-Methyl K (1)
- pan-Mono-Methyl K (1)
- pan-Mono-MethylR（R*GG） (1)
- pan-Myristyl-G (1)
- pan-TriMethyl-lysine (1)
- pan-tri-Methyl K (1)
- phospho S76 (1)
- succinylation K79 (1)
Assay Types
Families
- Druggable Genome (13399)
- Transmembrane (5970)
- Transcription Factors (4759)
- Secreted Protein (1716)
- Protein Kinase (1548)
- ES Cell Differentiation/IPS (1181)
- Stem cell - Pluripotency (941)
- Protease (790)
- GPCR (567)
- Nuclear Hormone Receptor (269)
- Phosphatase (257)
- Adult stem cells (251)
- Embryonic stem cells (227)
- Ion Channels: Other (216)
- Stem cell relevant signaling - JAK/STAT signaling pathway (178)
- Cancer stem cells (173)
- Induced pluripotent stem cells (144)
- P450 (124)
- Ion Channels: Potassium (123)
- Ion Channels: Cys-loop Receptors (94)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (88)
- Stem cell relevant signaling - DSL/Notch pathway (78)
- Stem cell relevant signaling - Wnt Signaling pathway (54)
- Ion Channels: Glutamate Receptors (48)
- Ion Channels: Transient receptor potential (30)
- Ion Channels: ATP Receptors (18)
- Ion Channels: Sodium (16)
- Ion Channels: Cyclic nucleotide gated (8)
- Ion Channels: Calcium (3)
Pathways
- Metabolic pathways (1818)
- Pathways in cancer (1554)
- MAPK signaling pathway (1019)
- Focal adhesion (802)
- Neurotrophin signaling pathway (673)
- Prostate cancer (635)
- Chemokine signaling pathway (627)
- Regulation of actin cytoskeleton (602)
- Cell cycle (590)
- Cytokine-cytokine receptor interaction (583)
- Neuroactive ligand-receptor interaction (572)
- Chronic myeloid leukemia (537)
- Colorectal cancer (536)
- Wnt signaling pathway (528)
- Pancreatic cancer (512)
- ErbB signaling pathway (508)
- Insulin signaling pathway (507)
- T cell receptor signaling pathway (504)
- Small cell lung cancer (469)
- Jak-STAT signaling pathway (466)
- Endocytosis (453)
- Apoptosis (451)
- Calcium signaling pathway (441)
- Leukocyte transendothelial migration (436)
- Huntington's disease (431)
- Alzheimer's disease (430)
- Toll-like receptor signaling pathway (425)
- Acute myeloid leukemia (405)
- Melanoma (390)
- B cell receptor signaling pathway (388)
- Progesterone-mediated oocyte maturation (388)
- Tight junction (385)
- Glioma (380)
- Natural killer cell mediated cytotoxicity (380)
- Adherens junction (374)
- Non-small cell lung cancer (374)
- Olfactory transduction (373)
- Endometrial cancer (366)
- Fc gamma R-mediated phagocytosis (366)
- Adipocytokine signaling pathway (361)
- VEGF signaling pathway (350)
- Axon guidance (348)
- GnRH signaling pathway (348)
- Oocyte meiosis (345)
- Melanogenesis (337)
- Renal cell carcinoma (332)
- Epithelial cell signaling in Helicobacter pylori infection (328)
- p53 signaling pathway (328)
- Fc epsilon RI signaling pathway (314)
- Gap junction (311)
- Ubiquitin mediated proteolysis (307)
- Vascular smooth muscle contraction (295)
- Bladder cancer (289)
- Amyotrophic lateral sclerosis (ALS) (287)
- TGF-beta signaling pathway (287)
- NOD-like receptor signaling pathway (267)
- RIG-I-like receptor signaling pathway (266)
- Systemic lupus erythematosus (245)
- Cell adhesion molecules (CAMs) (243)
- Parkinson's disease (241)
- Long-term potentiation (238)
- mTOR signaling pathway (236)
- Pathogenic Escherichia coli infection (233)
- Purine metabolism (230)
- Long-term depression (228)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (224)
- Dilated cardiomyopathy (213)
- Spliceosome (211)
- Hypertrophic cardiomyopathy (HCM) (207)
- Hematopoietic cell lineage (190)
- Thyroid cancer (187)
- Cytosolic DNA-sensing pathway (184)
- PPAR signaling pathway (177)
- Basal cell carcinoma (175)
- Viral myocarditis (174)
- Glycolysis / Gluconeogenesis (171)
- Type II diabetes mellitus (171)
- Lysosome (166)
- Complement and coagulation cascades (161)
- Antigen processing and presentation (157)
- Pyrimidine metabolism (154)
- Oxidative phosphorylation (153)
- Drug metabolism - cytochrome P450 (151)
- Metabolism of xenobiotics by cytochrome P450 (146)
- Notch signaling pathway (144)
- Arginine and proline metabolism (140)
- ECM-receptor interaction (135)
- Prion diseases (135)
- Vibrio cholerae infection (129)
- Nucleotide excision repair (126)
- Cardiac muscle contraction (125)
- Hedgehog signaling pathway (123)
- Phosphatidylinositol signaling system (123)
- Ribosome (120)
- Dorso-ventral axis formation (114)
- Retinol metabolism (113)
- Valine (113)
- Arachidonic acid metabolism (110)
- Primary immunodeficiency (109)
- Proteasome (107)
- RNA degradation (106)
- Tyrosine metabolism (104)
- Pyruvate metabolism (103)
- DNA replication (101)
- Drug metabolism - other enzymes (98)
- leucine and isoleucine degradation (98)
- Fatty acid metabolism (93)
- Glycerolipid metabolism (93)
- Base excision repair (92)
- Tryptophan metabolism (92)
- Glycerophospholipid metabolism (91)
- Basal transcription factors (88)
- Alanine (87)
- aspartate and glutamate metabolism (87)
- Glutathione metabolism (85)
- Fructose and mannose metabolism (84)
- Inositol phosphate metabolism (84)
- Maturity onset diabetes of the young (84)
- Butanoate metabolism (81)
- Homologous recombination (80)
- Lysine degradation (79)
- Cysteine and methionine metabolism (76)
- ABC transporters (75)
- Regulation of autophagy (75)
- Autoimmune thyroid disease (74)
- Sphingolipid metabolism (74)
- Type I diabetes mellitus (74)
- Citrate cycle (TCA cycle) (73)
- Amino sugar and nucleotide sugar metabolism (69)
- Taste transduction (68)
- Androgen and estrogen metabolism (65)
- Mismatch repair (65)
- Glycine (64)
- Histidine metabolism (64)
- Porphyrin and chlorophyll metabolism (64)
- serine and threonine metabolism (64)
- Starch and sucrose metabolism (63)
- Allograft rejection (62)
- Propanoate metabolism (62)
- Graft-versus-host disease (61)
- Nitrogen metabolism (61)
- Non-homologous end-joining (54)
- Pentose phosphate pathway (54)
- Aminoacyl-tRNA biosynthesis (52)
- Galactose metabolism (52)
- SNARE interactions in vesicular transport (52)
- beta-Alanine metabolism (51)
- Linoleic acid metabolism (50)
- Phenylalanine metabolism (47)
- Asthma (45)
- Renin-angiotensin system (45)
- Ether lipid metabolism (44)
- N-Glycan biosynthesis (42)
- Selenoamino acid metabolism (42)
- RNA polymerase (40)
- Pentose and glucuronate interconversions (38)
- Ascorbate and aldarate metabolism (36)
- Primary bile acid biosynthesis (36)
- Glycosaminoglycan degradation (34)
- Terpenoid backbone biosynthesis (31)
- Biosynthesis of unsaturated fatty acids (30)
- Circadian rhythm - mammal (30)
- Limonene and pinene degradation (30)
- O-Glycan biosynthesis (30)
- Glyoxylate and dicarboxylate metabolism (29)
- Nicotinate and nicotinamide metabolism (29)
- C21-Steroid hormone metabolism (26)
- One carbon pool by folate (26)
- Riboflavin metabolism (26)
- Chondroitin sulfate biosynthesis (24)
- Other glycan degradation (24)
- Folate biosynthesis (23)
- Heparan sulfate biosynthesis (22)
- Keratan sulfate biosynthesis (22)
- Glycosphingolipid biosynthesis - lacto and neolacto series (21)
- Taurine and hypotaurine metabolism (21)
- Glycosphingolipid biosynthesis - ganglio series (20)
- Synthesis and degradation of ketone bodies (19)
- leucine and isoleucine biosynthesis (19)
- Caffeine metabolism (18)
- Pantothenate and CoA biosynthesis (18)
- Steroid biosynthesis (18)
- alpha-Linolenic acid metabolism (17)
- Glycosphingolipid biosynthesis - globo series (15)
- Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (15)
- Sulfur metabolism (15)
- Fatty acid elongation in mitochondria (13)
- Fatty acid biosynthesis (12)
- Methane metabolism (12)
- Phenylalanine (12)
- tyrosine and tryptophan biosynthesis (12)
- Protein export (11)
- Vitamin B6 metabolism (11)
- Cyanoamino acid metabolism (10)
- Lysine biosynthesis (10)
- D-Glutamine and D-glutamate metabolism (9)
- Lipoic acid metabolism (6)
- Thiamine metabolism (6)
- O-Mannosyl glycan biosynthesis (4)
- Ubiquinone and other terpenoid-quinone biosynthesis (4)
- D-Arginine and D-ornithine metabolism (1)