Dysadherin (FXYD5) (NM_014164) Human Recombinant Protein
CAT#: TP761830
Purified recombinant protein of Human FXYD domain containing ion transport regulator 5 (FXYD5), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length FXYD5
|
Tag | N-GST and C-His |
Predicted MW | 45.2 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 50 mM Tris-HCl, pH 8.0, 8 M urea |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_054883 |
Locus ID | 53827 |
UniProt ID | Q96DB9 |
Cytogenetics | 19q13.12 |
Refseq Size | 914 |
Refseq ORF | 534 |
Synonyms | DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241; RIC |
Summary | This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009] |
Protein Families | Druggable Genome, Ion Channels: Other, Transmembrane |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC402284 | FXYD5 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 134.00 |
|
LC408093 | FXYD5 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 134.00 |
|
LC431776 | FXYD5 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 134.00 |
|
LY402284 | Transient overexpression lysate of FXYD domain containing ion transport regulator 5 (FXYD5), transcript variant 2 |
USD 436.00 |
|
LY408093 | Transient overexpression lysate of FXYD domain containing ion transport regulator 5 (FXYD5), transcript variant 1 |
USD 436.00 |
|
LY431776 | Transient overexpression lysate of FXYD domain containing ion transport regulator 5 (FXYD5), transcript variant 3 |
USD 436.00 |
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