IL1 Receptor I (IL1R1) Human Recombinant Protein
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Specifications
Product Data | |
Species | Human |
Protein Source | Human 293 |
Expression cDNA Clone or AA Sequence |
Asp21-Pro330
|
Tag | C-6His |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH7.4 |
Note | Recombinant Human IL-1R-1 is produced by our Mammalian expression system and the target gene encoding Asp21-Pro330 is expressed with a 6His tag at the C-terminus. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 3554 |
UniProt ID | P14778 |
Synonyms | Interleukin-1 receptor type 1; IL-1R-1; IL1R1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; p80; CD121a |
Summary | Interleukin 1 receptor, type I (IL-1R1) is an interleukin receptor that is a member of the interleukin-1 receptor family. IL-1R1 is expressed predominantly by T cells, fibroblasts, and endothelial cells. IL-1R1 mediates numerous cytokine-induced immune and inflammatory responses. It binds to interleukin-1 along with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binding of IL-1R1 to antagonist IL1RN prevents association with IL1RAP to form a signaling complex. |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Apoptosis, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.