P cadherin (CDH3) Human Recombinant Protein

CAT#: TP724791

Recombinant Human Cadherin-3/CDH3 (C-His)

Specifications

Product Data

• Species: Human
• Protein Source: Human 293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Glu25-Gly654
• Tag: C-6His
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
• Note: Recombinant Human Cadherin-3 is produced by our Mammalian expression system and the target gene encoding Glu25-Gly654 is expressed with a 6His tag at the C-terminus.
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 1001
• UniProt ID: P22223
• Synonyms: Cadherin-3; Placental Cadherin; P-Cadherin; CDH3; CDHP
• Summary: Cadherin-3 (CDH3), also known as placental cadherin, is a single-pass type I membrane protein that belongs to the cadherin superfamily. CDH3 is expressed in some normal epithelial tissues and some carcinoma cell lines. CDH3 is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. It preferentially binds to one another in a homophilic manner. CDH3 plays a role in development, specifically in tissue formation. CDH3 is also involved in the loss of heterozygosity events in breast and prostate cancer. Mutations in CDH3 have been associated with congenital hypotrichosis with juvenile macular dystrophy.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)