GM-CSF Human Protein
Product Images
Other products for "CSF2"
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Predicted MW | 14.5 kDa |
Purity | >98% > 98% by SDS-PAGE and HPLC analyses |
Presentation | Purified |
Buffer | Presentation State: Purified State: Lyophilized without stabilizer or preservative |
Bioactivity | Biological: Human GM-CSF is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is < / = 0.1 ng/ml. For most in vitro applications, human GM-CSF exerts its biologival activity in the concentration range of 0.05 - 0.5 ng/ml. Specific: 1x10e7 units/mg |
Endotoxin | < 0.1 ng per µg of GM-CSF |
Reconstitution | The lyophilized GM-CSF is soluble in water and most aqueous buffers. The lyophilized powder can be reconstituted in water to a concentration of 0.1 mg/ml. This solution can be diluted into other buffered solutions or stored at -20°C for future use. |
Preparation | Lyophilized without stabilizer or preservative |
Protein Description | Human GM-CSF is a 14,6 kDa protein consisting of 123 amino acid residues |
Storage | The lyophilized protein is stable for one year from despatch at -20°C. Reconstituted GM-CSF can be stored for three months in working aliquots at -20°C. Avoid repeated freezing and thawing. |
Reference Data | |
RefSeq | NP_000749 |
Locus ID | 1437 |
UniProt ID | P04141 |
Cytogenetics | 5q31.1 |
Synonyms | CSF; GMCSF |
Summary | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis. [provided by RefSeq, Aug 2020] |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein |
Protein Pathways | Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.