Kat8 Mouse Gene Knockout Kit (CRISPR)

CAT#: KN308589LP

Kat8 - mouse gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Donor DNA: Luciferase-Puro
• Symbol: Kat8
• Locus ID: 67773
• Components:

  KN308589G1, Kat8 gRNA vector 1 in pCas-Guide CRISPR vector

  KN308589G2, Kat8 gRNA vector 2 in pCas-Guide CRISPR vector

  KN308589LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_026370, NM_001360699
• UniProt ID: Q9D1P2
• Synonyms: 2010203C02Rik; 5830450F21Rik; D7Ertd629e; MOF; Myst1
• Summary: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.[UniProtKB/Swiss-Prot Function]