Hc Mouse Gene Knockout Kit (CRISPR)
CAT#: KN307599LP
Hc - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro RFP-BSD mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
Donor DNA | Luciferase-Puro |
Symbol | Hc |
Locus ID | 15139 |
Components |
KN307599G1, Hc gRNA vector 1 in pCas-Guide CRISPR vector KN307599G2, Hc gRNA vector 2 in pCas-Guide CRISPR vector KN307599LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_010406 |
UniProt ID | P06684 |
Synonyms | C5; C5a; He |
Summary | This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model. [provided by RefSeq, Nov 2015] |
Documents
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN307599 | Hc - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN307599BN | Hc - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN307599RB | Hc - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN507599 | Hc - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
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GA201852 | Hc CRISPRa kit - CRISPR gene activation of mouse hemolytic complement |
USD 1,657.00 |
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