IRG1 (ACOD1) Human Gene Knockout Kit (CRISPR)
CAT#: KN232825RB
IRG1 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | IRG1 |
Locus ID | 730249 |
Components |
KN232825G1, IRG1 gRNA vector 1 in pCas-Guide CRISPR vector KN232825G2, IRG1 gRNA vector 2 in pCas-Guide CRISPR vector KN232825RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001258406 |
UniProt ID | A6NK06 |
Synonyms | CAD |
Summary | Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
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Resources
Other Versions
SKU | Description | Size | Price |
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KN232825 | ACOD1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN232825BN | IRG1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN232825LP | IRG1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN432825 | ACOD1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
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GA119045 | ACOD1 CRISPRa kit - CRISPR gene activation of human aconitate decarboxylase 1 |
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