EMSY Human Gene Knockout Kit (CRISPR)

CAT#: KN216916LP

C11orf30 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Donor DNA: Luciferase-Puro
• Symbol: EMSY
• Locus ID: 56946
• Components:

  KN216916G1, EMSY gRNA vector 1 in pCas-Guide CRISPR vector

  KN216916G2, EMSY gRNA vector 2 in pCas-Guide CRISPR vector

  KN216916LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001300942, NM_001300943, NM_001300944, NM_020193
• UniProt ID: Q7Z589
• Synonyms: C11orf30; GL002
• Summary: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.[UniProtKB/Swiss-Prot Function]