ZNF451 Human Gene Knockout Kit (CRISPR)
CAT#: KN215720
ZNF451 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: Luciferase-Puro RFP-BSD mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control |
Donor DNA | GFP-puro |
Symbol | ZNF451 |
Locus ID | 26036 |
Components |
KN215720G1, ZNF451 gRNA vector 1 in pCas-Guide CRISPR vector KN215720G2, ZNF451 gRNA vector 2 in pCas-Guide CRISPR vector KN215720D, donor DNA containing left and right homologous arms and GFP-puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001031623, NM_001257273, NM_015555 |
UniProt ID | Q9Y4E5 |
Synonyms | COASTER; dJ417I1.1 |
Summary | E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN215720BN | ZNF451 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN215720LP | ZNF451 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN215720RB | ZNF451 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN415720 | ZNF451 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
|
GA108711 | ZNF451 CRISPRa kit - CRISPR gene activation of human zinc finger protein 451 |
USD 1,657.00 |
{0} Product Review(s)
Be the first one to submit a review