ATRX Human Gene Knockout Kit (CRISPR)
CAT#: KN215176RB
ATRX - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
USD 450.00
USD 3,084.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | ATRX |
Locus ID | 546 |
Components |
KN215176G1, ATRX gRNA vector 1 in pCas-Guide CRISPR vector KN215176G2, ATRX gRNA vector 2 in pCas-Guide CRISPR vector KN215176RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_000489, NM_138270, NM_138271 |
UniProt ID | P46100 |
Synonyms | ATR2; JMS; MRX52; MRXHF1; RAD54; RAD54L; SFM1; SHS; XH2; XNP; ZNF-HX |
Summary | The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017] |
Documents
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Other Versions
SKU | Description | Size | Price |
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KN215176 | ATRX - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN215176BN | ATRX - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN215176LP | ATRX - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN415176 | ATRX - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
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GA100377 | ATRX CRISPRa kit - CRISPR gene activation of human ATRX chromatin remodeler |
USD 1,657.00 |
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