CDC2L6 (CDK19) Human Gene Knockout Kit (CRISPR)

CAT#: KN206105LP

CDK19 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Donor DNA: Luciferase-Puro
• Symbol: CDC2L6
• Locus ID: 23097
• Components:

  KN206105G1, CDC2L6 gRNA vector 1 in pCas-Guide CRISPR vector

  KN206105G2, CDC2L6 gRNA vector 2 in pCas-Guide CRISPR vector

  KN206105LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001300960, NM_001300963, NM_001300964, NM_015076
• UniProt ID: Q9BWU1
• Synonyms: bA346C16.3; CDC2L6; CDK11
• Summary: This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]