TNFRSF1A Human Gene Knockout Kit (CRISPR)
CAT#: KN204008RB
TNFRSF1A - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
2 Weeks*
USD 450.00
USD 457.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | TNFRSF1A |
Locus ID | 7132 |
Components |
KN204008G1, TNFRSF1A gRNA vector 1 in pCas-Guide CRISPR vector KN204008G2, TNFRSF1A gRNA vector 2 in pCas-Guide CRISPR vector KN204008RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001065, NM_001346091, NM_001346092, NR_144351 |
UniProt ID | P19438 |
Synonyms | CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55 |
Summary | This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016] |
Documents
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN204008 | TNFRSF1A - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN204008BN | TNFRSF1A - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN204008LP | TNFRSF1A - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN404008 | TNFRSF1A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
|
GA104924 | TNFRSF1A CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 1A |
USD 1,657.00 |
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