Fc epsilon RI (FCER1A) Human Gene Knockout Kit (CRISPR)

CAT#: KN203321LP

FCER1A - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Donor DNA: Luciferase-Puro
• Symbol: Fc epsilon RI
• Locus ID: 2205
• Components:

  KN203321G1, Fc epsilon RI gRNA vector 1 in pCas-Guide CRISPR vector

  KN203321G2, Fc epsilon RI gRNA vector 2 in pCas-Guide CRISPR vector

  KN203321LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_002001
• UniProt ID: P12319
• Synonyms: FCE1A; FcERI
• Summary: The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]