TWEAKR (TNFRSF12A) Human Gene Knockout Kit (CRISPR)

CAT#: KN201041LP

TNFRSF12A - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Donor DNA: Luciferase-Puro
• Symbol: TWEAKR
• Locus ID: 51330
• Components:

  KN201041G1, TWEAKR gRNA vector 1 in pCas-Guide CRISPR vector

  KN201041G2, TWEAKR gRNA vector 2 in pCas-Guide CRISPR vector

  KN201041LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_016639
• UniProt ID: Q9NP84
• Synonyms: CD266; FN14; TWEAKR
• Summary: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.[UniProtKB/Swiss-Prot Function]