Mucolipin 1 (MCOLN1) Human Gene Knockout Kit (CRISPR)
CAT#: KN201010BN
MCOLN1 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro RFP-BSD
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
Donor DNA | mBFP-Neo |
Symbol | Mucolipin 1 |
Locus ID | 57192 |
Components |
KN201010G1, Mucolipin 1 gRNA vector 1 in pCas-Guide CRISPR vector KN201010G2, Mucolipin 1 gRNA vector 2 in pCas-Guide CRISPR vector KN201010BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_020533 |
UniProt ID | Q9GZU1 |
Synonyms | MG-2; ML4; MLIV; MST080; MSTP080; TRP-ML1; TRPM-L1; TRPML1 |
Summary | This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
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KN201010 | MCOLN1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN201010LP | MCOLN1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN201010RB | MCOLN1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN401010 | MCOLN1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
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GA111441 | MCOLN1 CRISPRa kit - CRISPR gene activation of human mucolipin 1 |
USD 1,657.00 |
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