Hexokinase 1 (HK1) Human Gene Knockout Kit (CRISPR)

CAT#: KN200464BN

HK1 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Donor DNA: mBFP-Neo
• Symbol: Hexokinase 1
• Locus ID: 3098
• Components:

  KN200464G1, Hexokinase 1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN200464G2, Hexokinase 1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN200464BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_000188, NM_001322364, NM_001322365, NM_001322366, NM_001322367, NM_033496, NM_033497, NM_033498, NM_033500, NM_001358263
• UniProt ID: P19367
• Synonyms: hexokinase; HK; HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1
• Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]