Mouse Gramd2 activation kit by CRISPRa

CAT#: GA217830

Gramd2 CRISPRa kit - CRISPR gene activation of mouse GRAM domain containing 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Gramd2
• Locus ID: 546134
• Kit Components:

  GA217830G1, Gramd2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA217830G2, Gramd2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA217830G3, Gramd2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001033498, NM_001357686
• UniProt ID: Q3V3G7
• Synonyms: BC064463
• Summary: Participates in the organization ofendoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).[UniProtKB/Swiss-Prot Function]