Mouse Marchf2 activation kit by CRISPRa

CAT#: GA213716

March2 CRISPRa kit - CRISPR gene activation of mouse membrane-associated ring finger (C3HC4) 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Marchf2
• Locus ID: 224703
• Kit Components:

  GA213716G1, Marchf2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA213716G2, Marchf2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA213716G3, Marchf2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001252480, NM_145486, NR_045522, NR_045523
• UniProt ID: Q99M02
• Synonyms: 9530046H09Rik; MARCH-II
• Summary: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.[UniProtKB/Swiss-Prot Function]