Mouse Marf1 activation kit by CRISPRa

CAT#: GA213658

Marf1 CRISPRa kit - CRISPR gene activation of mouse meiosis regulator and mRNA stability 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Marf1
• Locus ID: 223989
• Kit Components:

  GA213658G1, Marf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA213658G2, Marf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA213658G3, Marf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001081154
• UniProt ID: Q8BJ34
• Synonyms: 4921513D23Rik; BC031575; C87306; E030019O05; Lkap; mKIAA0430
• Summary: Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks.[UniProtKB/Swiss-Prot Function]