Mouse Ttll12 activation kit by CRISPRa

CAT#: GA213633

Ttll12 CRISPRa kit - CRISPR gene activation of mouse tubulin tyrosine ligase-like family, member 12

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Ttll12
• Locus ID: 223723
• Kit Components:

  GA213633G1, Ttll12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA213633G2, Ttll12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA213633G3, Ttll12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_183017
• UniProt ID: Q3UDE2
• Synonyms: BC055368; D430005B17
• Summary: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.[UniProtKB/Swiss-Prot Function]