Mouse Socs7 activation kit by CRISPRa

CAT#: GA212688

Socs7 CRISPRa kit - CRISPR gene activation of mouse suppressor of cytokine signaling 7

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Socs7
• Locus ID: 192157
• Kit Components:

  GA212688G1, Socs7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA212688G2, Socs7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA212688G3, Socs7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_138657
• UniProt ID: Q8VHQ2
• Synonyms: 2310063P06Rik; C85125; Nap4
• Summary: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).[UniProtKB/Swiss-Prot Function]