Mouse Ibtk activation kit by CRISPRa

CAT#: GA212150

Ibtk CRISPRa kit - CRISPR gene activation of mouse inhibitor of Bruton agammaglobulinemia tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Ibtk
• Locus ID: 108837
• Kit Components:

  GA212150G1, Ibtk gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA212150G2, Ibtk gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA212150G3, Ibtk gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001081282, NM_175371
• UniProt ID: Q6ZPR6
• Synonyms: 5430411K16Rik; AA409502; BTKI; mKIAA1417
• Summary: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity).[UniProtKB/Swiss-Prot Function]