Mouse Xrcc4 activation kit by CRISPRa

CAT#: GA212098

Xrcc4 CRISPRa kit - CRISPR gene activation of mouse X-ray repair complementing defective repair in Chinese hamster cells 4

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Xrcc4
• Locus ID: 108138
• Kit Components:

  GA212098G1, Xrcc4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA212098G2, Xrcc4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA212098G3, Xrcc4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_028012
• UniProt ID: Q924T3
• Synonyms: 2310057B22Rik; AW413319; AW545101
• Summary: Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (By similarity).[UniProtKB/Swiss-Prot Function]