Mouse Scrib activation kit by CRISPRa

CAT#: GA211892

Scrib CRISPRa kit - CRISPR gene activation of mouse scribbled planar cell polarity

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Scrib
• Locus ID: 105782
• Kit Components:

  GA211892G1, Scrib gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA211892G2, Scrib gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA211892G3, Scrib gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001310542, NM_001310543, NM_134089
• UniProt ID: Q80U72
• Synonyms: AI118201; Crc; CRIB; mKIAA0147; Scrb1; SCRIB1; vartul
• Summary: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.[UniProtKB/Swiss-Prot Function]