Mouse Arid4b activation kit by CRISPRa

CAT#: GA211444

Arid4b CRISPRa kit - CRISPR gene activation of mouse AT rich interactive domain 4B (RBP1-like)

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Arid4b
• Locus ID: 94246
• Kit Components:

  GA211444G1, Arid4b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA211444G2, Arid4b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA211444G3, Arid4b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_194262, NM_198122
• UniProt ID: A2CG63
• Synonyms: BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180
• Summary: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A (PubMed:17043311). Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (PubMed:18728284).[UniProtKB/Swiss-Prot Function]