Mouse Elovl4 activation kit by CRISPRa

CAT#: GA211244

Elovl4 CRISPRa kit - CRISPR gene activation of mouse elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Elovl4
• Locus ID: 83603
• Kit Components:

  GA211244G1, Elovl4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA211244G2, Elovl4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA211244G3, Elovl4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145974, NM_148941
• UniProt ID: Q9EQC4
• Summary: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.[UniProtKB/Swiss-Prot Function]