Mouse Fblim1 activation kit by CRISPRa

CAT#: GA209782

Fblim1 CRISPRa kit - CRISPR gene activation of mouse filamin binding LIM protein 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Fblim1
• Locus ID: 74202
• Kit Components:

  GA209782G1, Fblim1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA209782G2, Fblim1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA209782G3, Fblim1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001163256, NM_133754
• UniProt ID: Q71FD7
• Synonyms: 2410043F08Rik; Cal; Fblp1; Gt10; migfilin; migfilin(s)
• Summary: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity).[UniProtKB/Swiss-Prot Function]