Mouse Tspan15 activation kit by CRISPRa

CAT#: GA208515

Tspan15 CRISPRa kit - CRISPR gene activation of mouse tetraspanin 15

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Tspan15
• Locus ID: 70423
• Kit Components:

  GA208515G1, Tspan15 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA208515G2, Tspan15 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA208515G3, Tspan15 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_197996
• UniProt ID: F7BWT7
• Synonyms: 1110036D12Rik; 2700063A19Rik; AW048364; Tm4sf15
• Summary: Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:23035126, PubMed:26668317). Promotes ADAM10-mediated cleavage of (CDH2) (PubMed:26668317). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity).[UniProtKB/Swiss-Prot Function]