Mouse Derl3 activation kit by CRISPRa

CAT#: GA208497

Derl3 CRISPRa kit - CRISPR gene activation of mouse Der1-like domain family, member 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Derl3
• Locus ID: 70377
• Kit Components:

  GA208497G1, Derl3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA208497G2, Derl3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA208497G3, Derl3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_024440, NM_001358983, NM_001358984, NM_001358985, NR_152573, NR_152574
• UniProt ID: Q9D8K3
• Synonyms: 1810006I20Rik; 1810063P04Rik; derlin-3; IZP6
• Summary: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.[UniProtKB/Swiss-Prot Function]