Mouse Fuom activation kit by CRISPRa

CAT#: GA208038

Fuom CRISPRa kit - CRISPR gene activation of mouse fucose mutarotase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Fuom
• Locus ID: 69064
• Kit Components:

  GA208038G1, Fuom gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA208038G2, Fuom gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA208038G3, Fuom gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286217, NM_001286218, NM_026928, NR_104415
• UniProt ID: Q8R2K1
• Synonyms: Fucu; Le51
• Summary: Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.[UniProtKB/Swiss-Prot Function]